Role of Plasma MMP 9 levels in the Pathogenesis of Chronic Pancreatitis |
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| Authors: | A Venkateshwari K Sri Manjari D Krishnaveni Pratibha Nallari A Vidyasagar A Jyothy |
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| Institution: | (1) Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad, 500016, India;(2) Department of Genetics, Osmania University, Hyderabad, 500007, India;(3) Department of Gastroenterology, Gandhi Hospital, Secunderabad, 500003, India |
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| Abstract: | Pancreatic fibrosis is a key pathological feature in the etiology of chronic pancreatitis that leads to obliteration of exocrine
and endocrine pancreatic tissues and its replacement by fibrous tissue resulting in clinical manifestations. Matrix metalloproteinase
9 is a member of the MMP family that is also known as gelatinase B, degrades type IV collagen of extracellular matrix and
basal membrane. The present study is aimed at evaluating the clinical significance of plasma concentration of MMP-9 in chronic
pancreatitis. The samples were obtained from 112 chronic pancreatitis patients and an equal number of age and sex matched
healthy controls. MMP-9 levels were quantitatively measured by ELISA assay. Statistical analysis was applied to test the significance
of results. The present study revealed a significant increase of plasma MMP 9 levels in chronic pancreatitis patients compared
to control subjects. Elevated levels were also observed in all the patient groups compared to control subjects with regard
to sex, age, addictions etc. MMP-9 degrades the type IV collagens in normal basement membrane, which in turn activates the
pancreatic stellate cells which promote the development of pancreatitic fibrosis. Thus, elevated plasma levels of MMP-9 may
act as a susceptibility factor for the development of chronic pancreatitis. |
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| Keywords: | Chronic pancreatitis Pancreatic stellate cells Extracellular matrix |
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