| Studies on Pongamia pinnata （L.） Pierre leaves： understanding the mechanism（s） of action in infectious diarrhea |
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| 作者姓名： | Brijesh S Daswani PG Tetali P Rojatkar SR Antia NH Birdi TJ |
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| 作者单位： | [1]The Foundation for Medical Research, R.G. Thadani Marg, Worli, Mumbai 400018, India [2]Naoroji Godrej Centre for Plant Research, Lawkin Ltd. Campus, Shindewadi, Shirwal, Satara 412801, India [3]The National Chemical Laboratory, Homi Bhabha Road, Pune 411008, India [4]The Foundation for Research in Community Health, Anand Park, Pune 411007, India |
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| 基金项目： | Project (No. 91283) supported by the Department of Science and Technology, Ministry of Science and Technology, Government ofIndia |
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| 摘 要： | While data are available on the effect of medicinal plants on intestinal motility and their antibacterial action, there is a paucity of information on their mode of action on various aspects of diarrheal pathogenicity, namely colonization to intestinal epithelial cells and production/action of enterotoxins. Crude decoction of dried leaves of Pongamia pinnata was evaluated for its antimicrobial （antibacterial, antigiardial and antirotaviral） effect; and its effect on production and action of enterotoxins （cholera toxin, CT; Escherichia coli labile toxin, LT; and E. coli stable toxin, ST）; and adherence of enteropathogenic E. coli and invasion of enteroinvasive E. coli and Shigellaflexneri to epithelial cells. The decoction had no antibacterial, antigiardial and antirotaviral activity, but reduced production of CT and bacterial invasion to epithelial cells. The observed results indicated that the crude decoction ofP. pinnata has selective antidiarrheal action with efficacy against cholera and enteroinvasive bacterial strains causing bloody diarrheal episodes.
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| 关 键 词： | 药用植物 腹泻 止泻药 肠毒素 移生 |
| 收稿时间： | 2006-03-09 |
| 修稿时间： | 2006-06-02 |
Studies on Pongamia pinnata (L.) Pierre leaves: understanding the mechanism(s) of action in infectious diarrhea |
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| Brijesh S,Daswani PG,Tetali P,Rojatkar SR,Antia NH,Birdi TJ.Studies on Pongamia pinnata (L.) Pierre leaves: understanding the mechanism(s) of action in infectious diarrhea[J].Journal of Zhejiang University Science,2006,7(8):665-674. |
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| Authors: | S Brijesh P G Daswani P Tetali S R Rojatkar N H Antia T J Birdi |
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| Institution: | (1) The Foundation for Medical Research, R.G. Thadani Marg, Worli, Mumbai, 400018, India;(2) Naoroji Godrej Centre for Plant Research, Lawkin Ltd. Campus, Shindewadi, Shirwal, Satara, 412801, India;(3) The National Chemical Laboratory, Homi Bhabha Road, Pune, 411008, India;(4) The Foundation for Research in Community Health, Anand Park, Pune, 411007, India |
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| Abstract: | While data are available on the effect of medicinal plants on intestinal motility and their antibacterial action, there is a paucity of information on their mode of action on various aspects of diarrheal pathogenicity, namely colonization to intestinal epithelial cells and production/action of enterotoxins. Crude decoction of dried leaves of Pongamia pinnata was evaluated for its antimicrobial (antibacterial, antigiardial and antirotaviral) effect; and its effect on production and action of enterotoxins (cholera toxin, CT; Escherichia coli labile toxin, LT; and E. coli stable toxin, ST); and adherence of enteropathogenic E. coli and invasion of enteroinvasive E. coli and Shigella flexneri to epithelial cells. The decoction had no antibacterial, antigiardial and antirotaviral activity, but reduced production of CT and bacterial invasion to epithelial cells. The observed results indicated that the crude decoction of P. pinnata has selective antidiarrheal action with efficacy against cholera and enteroinvasive bacterial strains causing bloody diarrheal episodes. |
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| Keywords: | Pongamia pinnata Medicinal plants Diarrhea Antidiarrheal agent Enterotoxin Colonization |
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