Propolis modulates vitronectin, laminin, and heparan sulfate/heparin expression during experimental burn healing |
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| Authors: | Pawe? Olczyk Katarzyna Komosińska-Vassev Katarzyna Winsz-Szczotka Ewa M Ko?ma Grzegorz Wisowski Jerzy Stojko Katarzyna Klimek Krystyna Olczyk |
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| Institution: | 1Department of Clinical Chemistry and Laboratory Diagnostics, Medical University of Silesia, 41-200 Sosnowiec, Poland;2Center of Experimental Medicine, Medical University of Silesia, 40-752 Katowice, Poland;3Department of Statistics, Medical University of Silesia, 41-200 Sosnowiec, Poland |
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| Abstract: | Objective This study was aimed at assessing the dynamics of vitronectin (VN), laminin (LN), and heparan sulfate/heparin (HS/HP) content changes during experimental burn healing. Methods VN, LN, and HS/HP were isolated and purified from normal and injured skin of domestic pigs, on the 3rd, 5th, 10th, 15th, and 21st days following thermal damage. The wounds were treated with apitherapeutic agent (propolis), silver sulfadiazine (SSD), physiological salt solution, and propolis vehicle. VN and LN were quantified using an immunoenzymatic assay and HS/HP was estimated by densitometric analysis. Results Propolis treatment stimulated significant increases in VN, LN, and HS/HP contents during the initial phase of study, followed by a reduction in the estimated extracellular matrix molecules. Similar patterns, although less extreme, were observed after treatment with SSD. Conclusions The beneficial effects of propolis on experimental wounds make it a potential apitherapeutic agent in topical burn management. |
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| Keywords: | Apitherapeutic agent Silver sulfadiazine Laminin Vitronectin Heparan sulfate/heparin Wound healing |
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