A mixed design reveals that glucose moieties facilitate extinction of a conditioned taste aversion in rats |
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| Authors: | Michael E Smith Ralph Norgren Patricia Sue Grigson |
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| Institution: | Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA. mes32@psu.edu |
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| Abstract: | Separate groups of water-deprived rats had four trials with 15-min access to 0.0073 M saccharin, 0.3 M alanine, 0.3 M glucose,
0.1 M maltose, 0.3 M fructose, 0.06 M sucrose, or 0.03 M Polycose. Trials 1–3 were followed by injections of either 0.15 M
LiCl (1.33 ml/100 g b.w., i.p.) or saline; Trial 4 (Test) was CS only. Extinction included either 48-h access to water alone
or to the appropriate CS, both followed by a 24-h, two-bottle choice of CS and water. This 3-day cycle was repeated five to
six times. All rats acquired comparable conditioned taste aversions (CTAs), but extinction rates varied with the test and
the taste CS. No CTA extinguished during the two-bottle choices following 2 water days. During one-bottle CS exposure, all
CTAs extinguished, but the aversion continued longer in the probe two-bottle tests. Intake of glucose moieties recovered rapidly,
often in two cycles; the other CSs took four to six cycles. Thus, CTA extinction varies with the nature of the taste CS. |
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