Maternal and fetal indicators of oxidative stress during intrauterine growth retardation (IUGR) |
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| Authors: | Ullas Kamath Guruprasad Rao Shobha U Kamath Lavanya Rai |
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| Institution: | (1) Department of Biochemistry, Melaka Manipal Medical College, 576 104 Manipal, Karnataka, India;(2) Department of Biochemistry, Kasturba Medical College, Manipal;(3) Department of Obstetrics and Gynaecology, Kasturba Medical College, Manipal |
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| Abstract: | The present study demonstrates the possibility of increased lipid peroxidation and protein oxidation in both maternal and
fetal erythrocytes as markers of oxygen radical activity during intrauterine growth retardation. The erythrocyte MDA levels
were significantly elevated in mothers of IUGR babies when compared to controls (p<0.01). The endogenous protein damage due
to oxidative stress was significantly higher in IUGR mothers when compared to controls (p<0.05). Similarly the proteolytic
activity in erythrocyte lysates against oxidatively damaged hemoglobin was significantly increased in mothers of IUGR babies
compared to controls (p<0.001).
In fetuses born with IUGR, both lipid peroxidation and proteolytic activity were significantly increased when compared to
normal newborns (p<0.01).
The result of this study indicates that oxidative stress was induced both in IUGR babies and their mothers which is manifested
as increased lipid peroxidation and protein oxidant damage. |
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| Keywords: | Intrauterine growth retardation malodialdehyde proteolytic activity |
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