| 血管内皮生长因子936~*T/C基因多态性与胃癌的关系 |
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| 引用本文： | 林伟,陈金坤,邱仙土,陈凯.血管内皮生长因子936~*T/C基因多态性与胃癌的关系[J].莆田学院学报,2012,19(5):33-35,74. |
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| 作者姓名： | 林伟 陈金坤 邱仙土 陈凯 |
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| 作者单位： | 莆田学院附属医院普通外科,福建莆田,351100 |
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| 基金项目： | 福建省自然科学基金资助项目，莆田市科技局基金资助项目 |
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| 摘 要： | 研究血管内皮生长因子(VEGF)936*T/C基因多态性与胃癌之间的关系,了解该基因多态性对胃癌生成及发展的影响。采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法检测胃癌患者和健康者外周血的VEGF936*T/C基因型。结果,胃癌患者外周血中VEGF936*T/C基因型或等位基因与健康者相比无差异(精确概率法计算基因型P=0.226;卡方检验等位基因x2=2.934,P=0.087)。Ⅲ、Ⅳ期病理分期患者C/C基因型和C等位基因比例(66.7%和82.0%)明显大于Ⅰ、Ⅱ期(12.9%和1.2%),两者差异有统计学意义(基因型:x2=14.215,P=0.000;等位基因:x2=28.430,P=0.000)。结果表明,VEGF936*C/C基因多态性与胃癌的生成无关,而与胃癌的进展相关。
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| 关 键 词： | VEGF 胃癌 基因多态性 |
Relationship between VEGF Gene 936^*T/C Polymorphism and Gastric Cancer |
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| LIN Wei,CHEN Jin-kun,QIU Xian-tu,CHEN Kai.Relationship between VEGF Gene 936^*T/C Polymorphism and Gastric Cancer[J].journal of putian university,2012,19(5):33-35,74. |
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| Authors: | LIN Wei CHEN Jin-kun QIU Xian-tu CHEN Kai |
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| Institution: | (Department of General Surgery,The Affiliated Hospital of Putian University,Putian Fujian 351100,China) |
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| Abstract: | Objective The study was to investigate the relationship between VEGF gene 936 * T/C polymorphism and gastric cancer.Methods VEGF936 * T/C genotypes was detected by PCR-RFLP in patients with gastric carcinoma and healthy controls.Results There was no significant difference in the gentype of VEGF936* T/C or C allele between the patients and the control group(genotype P = 0.226;C allele x 2 = 2.934,P = 0.087).The C/C genotype and C allele in patients at Ⅲ,Ⅳ staged(66.7 % and 82.0 %) were more frequently found than in those with Ⅰ,Ⅱ staged(12.9 % and 1.2 %),so there was significant difference(C/C genotype;(x 2 = 14.215,P = 0.000.C allele x 2 = 28.430,P = 0.000).Conclusions VEGF936*C/C genotype is not related to the development of gastric carcinoma,but they both are related to the growth of the carcinoma. |
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| Keywords: | VEGF gastric cancer gene polymorphism |
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