| 两种家兔急性肾功能衰竭模型复制的方法学比较 |
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| 引用本文： | 赵自刚,牛春雨,侯亚利,张静,郭春燕,姜华,樊贵.两种家兔急性肾功能衰竭模型复制的方法学比较[J].河北北方学院学报(医学版),2004,21(5):15-17. |
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| 作者姓名： | 赵自刚 牛春雨 侯亚利 张静 郭春燕 姜华 樊贵 |
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| 作者单位： | 河北北方学院病理生理教研室,075000 |
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| 基金项目： | 河北省张家口市科技局科研项目 |
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| 摘 要： | 目的:探讨两种家兔急性肾功能衰竭(ARF)模型的方法学差异.方法:皮下注射1%HgCl2(1.5ml/kg.bw,H组)、肌肉注射50%甘油(5.6ml/kg.bw、8ml/kg.bw、10ml/kg.bw三种剂量,依次为G1组、G2组、G3组)复制家兔ARF模型,测定24h和48h血清尿素氮(BUN)和肌酐(Cre)水平,观察比较各组模型复制的成功率、存活率及稳定性.结果:G1、G2两组不能成功复制ARF模型;G3组BUN、Cre较H组降低(P＜0.05).但G3组的存活率及稳定性均显著高于H组(P＜0.05).结论:两种模型复制方法各有优缺点,应根据不同研究目的选择相应的模型.
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| 关 键 词： | 急性肾功能衰竭 甘油 模型 家兔 |
| 文章编号： | 1005-8796(2004)05-0015-03 |
Copying Method Comparison on Two Models of Acute Renal Failure in Rabbits |
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| Zhao Zigang,Niu Chunyu,Hou Yali,et al.Copying Method Comparison on Two Models of Acute Renal Failure in Rabbits[J].Journal of Hebei North University:Medical Edition,2004,21(5):15-17. |
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| Authors: | Zhao Zigang Niu Chunyu Hou Yali |
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| Institution: | Zhao Zigang,Niu Chunyu,Hou Yali,et al Department of Pathophysiology,Hebei North University,Zhangjiakou 075000,China |
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| Abstract: | Objective: To study the copying method comparison on two model of acute renal failure in rabbits. Methods: The rabbit models of acute renal failure were copied by hypodermic injection HgCl 2(1.5ml/kg.bw,H group)and intramuscular injection 50% glycerinum(5.6ml/kg.bw, 8ml/kg.bw, 10ml/kg.bw three doses, in turn G 1 group, G 2 group, G 3 group), the BUN and Cre contents in serum were determined at 24 hours and 48 hours. Observed and compared successful rate, survival rate and stability of models in different groups. Results: It showed that the G 1 group and G 2 group were not successful, the serum BUN, Cre of G 3 group were significantly lower than those of the H group (P<0.05). But the survival rate and stability of G 3 group were significantly increased compared with H group (P<0.05). Conclusion: There are advantages and disadvantages in two ARF model, we should choose corresponding model according to different aim. |
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| Keywords: | acute renal failure glycerinum model rabbit |
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