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| 川芎嗪治疗实验性肾损伤机理的研究 | |
| 引用本文： | 谭洪华,李霞,薄爱华,邢立强,薛贵平.川芎嗪治疗实验性肾损伤机理的研究[J].河北北方学院学报(医学版),2007,24(4):7-9. |
| 作者姓名： | 谭洪华 李霞 薄爱华 邢立强 薛贵平 |
| 作者单位： | 1. 河北北方学院教务处,河北,张家口,075000 2. 张家口市社会福利总院,河北,张家口,075000 3. 河北北方学院实验中心,河北,张家口,075000 4. 河北北方学院药理教研室,河北,张家口,075000 |
| 摘 要： | 目的:观察川芎嗪治疗实验性免疫性肾损伤作用和机理,为中药治疗肾小球肾炎开辟新途径。方法:猪血清腹腔注射8周,复制大鼠实验性肾损伤模型,川芎嗪治疗4周后处死动物,检测尿蛋白、血清BUN和Scr含量,取肾组织制作光、电镜标本检查。结果:川芎嗪大、小剂量组尿蛋白、血清BUN和Scr含量较模型组明显降低(P<0.01),肾小球的病理形态学改变较模型组轻。结论:川芎嗪具有治疗大鼠实验性免疫性肾损伤的作用。 |
| 关 键 词： | 川芎嗪 肾损伤 药理学 疾病模型 大鼠 |
| 文章编号： | 1673-1484（2007）04-0007-03 |
Study on the Treating Mechanism of Tetramethylpyrazine on Experimental Immune Renal Injury |
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| TAN Hong-hua, LI Xia,BO Ai-hua,et al.Study on the Treating Mechanism of Tetramethylpyrazine on Experimental Immune Renal Injury[J].Journal of Hebei North University:Medical Edition,2007,24(4):7-9. | |
| Authors: | TAN Hong-hua LI Xia BO Ai-hua |
| Institution: | Hebei North University, Zhangjiakou, 075000, Hebei, China |
| Abstract: | Objective: To further investigate possible ways for treating immune renal injury by traditional Chinese medicine Tetramethylpyrazine(T).Methods: Rats were administrated intra-abdominally fresh swine serum to induce immune renal ingury model and then were treated with Tetramethylpyrazine respectively.Urine protein(UP),serum BUN and Scr were measured and the kidney specimens were taken from abdomen and prepared for light and electron microscopic examiniation.Results: The above UP and serum parameters in T group did have significant differences with that of model control group(P<0.01).Light and electron microscopic examiniation showed that,compared with model control group,no obvious pathological changes were found in the kidney of T group.Conclusion: Tetramethylprazine has the effect of anti immune renal injury in rats. |
| Keywords: | Tetramethylprazine Renal injury Pharmacology Disease model Rat |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |