| 基于蛋白质互作网络的功能模块挖掘 |
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| 引用本文： | 马晔,孙红梅.基于蛋白质互作网络的功能模块挖掘[J].科技通报,2012,28(8):26-28. |
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| 作者姓名： | 马晔 孙红梅 |
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| 作者单位： | 哈尔滨医科大学生物信息科学与技术学院,哈尔滨,150081 |
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| 摘 要： | 有一些研究已经表明生物系统是由功能模块间的相互作用组成的。因此,鉴别这些功能模块对于理解生物系统的模块性和组织结构是十分必要的。本文提出了一个框架来鉴别功能模块通过整合蛋白质互作网络和基因表达谱数据。应用算法于双重加权酵母蛋白质互作网络中,得到了120个功能模块。这些模块显著的富集在蛋白质相关的GO的生物学过程上。因此,本文提出的算法可以很好的挖掘蛋白质互作网络中功能模块。
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| 关 键 词： | 蛋白质互作网络 基因表达 功能模块 |
Identification of Functional Modules from Protein-protein Interaction Network |
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| MA Ye
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SUN Hongmei.Identification of Functional Modules from Protein-protein Interaction Network[J].Bulletin of Science and Technology,2012,28(8):26-28. |
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| Authors: | MA Ye SUN Hongmei |
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| Institution: | (College of Bioinformatics Science and Technology,Harbin Medical University,Harbin 150081,China) |
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| Abstract: | Some studies suggest that biological systems are composed of interacting functional modules.Thus,the identification of these functional modules is essential to understand the modularity and organization of biological systems.In this paper,we propose a framework for identify functional modules which utilize protein-protein interaction(PPI) network and gene expression profiles.Application of our algorithm to the PPI network of yeast,we obtain 120 functional modules.These modules are significantly enriched in biological processes Gene Ontology terms.Thus,the algorithm we propose is well to identify functional modules in PPI network. |
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| Keywords: | protein-protein interaction network gene expression functional module |
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