| 混合药膜包膜系统释放动力学研究 |
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| 引用本文： | 石巍,张国亮,张凤宝,刘瑛.混合药膜包膜系统释放动力学研究[J].天津大学学报(英文版),2001,7(1):56-60. |
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| 作者姓名： | 石巍 张国亮 张凤宝 刘瑛 |
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| 作者单位： | 天津大学化工学院, |
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| 摘 要： | 存储混合型是目前研究较多的控制释放体系 ,但由于其机理较为复杂 ,目前尚未建立合理实用的动力学模型 .以混合药膜包膜体系为研究对象 ,建立了释放动力学的简化模型并获得了解析解 .实验数据表明 ,该模型适用于描述药物装填量大于饱和溶解度的药物释放动力学行为 (相对偏差小于 3 % ) .根据该模型还从理论上分析了两种限定条件 (Dm Df和 Dm Df)下药物的释放特征 :当 Dm Df时 ,释放速率变为常数 ,达到零级释放 ,其释放速率与药膜无关 ,这为零级释放缓释体系如何控制释放速率和药物释放量提供了理论依据 :当 Dm Df时 ,药物的释放速率与药膜中的释放系数、溶解度和药物的装填量有关 ,与包膜过程无关 ,其释放过程类似于混合药膜缓释体系
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| 关 键 词： | 控制释放 扩散 巯嘌呤 混合药膜 包膜 |
RELEASE KINETICS OF MONOLITHIC MATRIX COATED WITH OUTER MEMBRANE SYSTEM |
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| SHI Wei,ZHANG Guo-liang,ZHANG Feng-bao,LIU Ying.RELEASE KINETICS OF MONOLITHIC MATRIX COATED WITH OUTER MEMBRANE SYSTEM[J].Transactions of Tianjin University,2001,7(1):56-60. |
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| Authors: | SHI Wei ZHANG Guo-liang ZHANG Feng-bao LIU Ying |
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| Abstract: | The reservoir-monolithic type of the controlled release systems is investigated currently,how ever,the existing kinetic model could not describe the release process well beca use the release kinetics is rather complicated.In this paper,a simplified release kinetic model for diffusion-controlled monolithic matrix coated with outer me mbrane systems is proposed and verified by the experimental data of mercaptopur inum release experiment.It shows that the model can well describe the release mechanism (the relative error is under 3%) when drug loading (Cd) is above its solubility limit (Cs)．At the sam e time,the release characteristics of special cases (DmDf and D mDf) are discussed theoretically.When DmDf the release rate becomes constant,namely,zero order release,and the release rate is independent of the drug membrane.This res ult provides the theoretical basis for the system of zero order release as well as how to control the release rate and the amount of drug release.When DmDf,the release rate is dependent on the drug release coefficient in the monolithic matrix,solubility and drug loading but indep endent of the process in the outer membrane,and it is similar to monolithic matrix type. |
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| Keywords: | controlled release diffusion mercaptopurinum monolithic matrix outer membrane |
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