| Review:Protein folding pathology in domestic animals |
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| 作者姓名： | GRUYS Erik |
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| 作者单位： | Section of |
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| 基金项目： | Paper presented at the 27th Seminar on Recent Advances in Animal Health and Production, 22 March 2004, Universiti Putra Malaysia, Kuala Lumpur, Malaysia |
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| 摘 要： | Fibrillar proteins form structural elements of cells and the extracellular matrix. Pathological lesions of fibrillar microanatomical structures, or secondary fibrillar changes in globular proteins are well known. A special group concerns histologically amorphous deposits, amyloid. The major characteristics of amyloid are: apple green birefringence after Congo red staining of histological sections, and non-branching 7-10 nm thick fibrils on electron microscopy revealing a high content of cross beta pleated sheets. About 25 different types of amyloid have been characterised. In animals, AA-amyloid is the most frequent type. Other types of amyloid in animals represent: AIAPP (in cats), AApoAI, AApoAII, localised AL-amyloid, amyloid in odontogenic or mammary tumors and amyloid in the brain. In old dogs Ap and in sheep APrPsc-amyloid can be encountered. AA-amyloidosis is a systemic disorder with a precursor in blood, acute phase serum amyloid A (SAA). In chronic inflammatory processes AA-amyloid can be depos
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Review:Protein folding pathology in domestic animals |
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| GRUYS Erik.Review:Protein folding pathology in domestic animals[J].Journal of Zhejiang University Science,2004(10). |
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| Authors: | GRUYS Erik |
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| Abstract: | |
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| Keywords: | Extracellular fibrils Amyloid Amyloid enhancing factor Prion PrP Spongiform encephalopathy Alzheimer's disease |
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