Studies on the antiperoxide and antihaemolytic action of polyamines using human erythrocytes |
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| Authors: | Chethana Chetan Ashok Prabhu Vivian D'Souza Shrinivas B Rao |
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| Institution: | (1) Department of Biochemistry, Kasturba Medical College, 575 001 Mangalore |
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| Abstract: | Blood RBC's were used to study the role of polyamines, putrescine, spermidine and spermine individually as antioxidants against
the peroxidative action of H2O2 which leads to haemolysis of erythrocytes. Results indicated that putrescine did not act as antioxidant at all concentrations
used in our studies. However, spermidine and spermine suppressed peroxidative changes in RBC's due to the action of H2O2 and this suppression was greater with higher concentration of these individual polyamines used, separately. Further, all
the three polyamines decreased haemolysis of erythrocytes at all concentrations studied. The action of putrescine to suppress
haemolysis of RBC's without showing antioxidant property hypothetically suggests that these properties of respective polyamines
may have independent mechanism of action. |
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| Keywords: | Putrescine spermidine spermine lipid peroxidation erythrocytes haemolysis |
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