| 黄嘌呤氧化还原酶钼中心与配体的相互作用 |
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| 引用本文： | 王传铭,张旭东,王栋,谢昆.黄嘌呤氧化还原酶钼中心与配体的相互作用[J].蒙自师范高等专科学校学报,2013(2):45-51. |
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| 作者姓名： | 王传铭 张旭东 王栋 谢昆 |
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| 作者单位： | 1. 红河学院云南省高校农作物优质高效栽培与安全控制实验室云南蒙自661100
2. 云南大学生命科学学院昆明650091 |
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| 基金项目： | 红河学院中青年学术带头人后备人才基金(2010PY0104);红河学院科研基金项目(项目编号10XJY113) |
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| 摘 要： | 黄嘌呤氧化还原酶是一种分布广泛的核酸代谢调控酶类,过渡金属钼和蝶呤等辅因子构成其主要的催化活性位点.本文根据PDB数据库中现存的晶体结构和国内外学者多年来在此酶的催化过程、抑制机制等方面开展的实验和理论研究,对其钼中心与底物和抑制剂之间的相互作用形式进行了综述。
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| 关 键 词： | 黄嘌呤氧化还原酶 抑制剂 底物 钼辅因子 分子模拟 |
The Interaction between Molybdopterin Cofactor of Xanthine Oxidoreductase and Relative Ligands |
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| WANG Chuan-ming,ZHANG Xu-dong,WANG Dong,XIE Kun.The Interaction between Molybdopterin Cofactor of Xanthine Oxidoreductase and Relative Ligands[J].Journal of Mengzi Teachers' College,2013(2):45-51. |
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| Authors: | WANG Chuan-ming ZHANG Xu-dong WANG Dong XIE Kun |
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| Institution: | 1(1.University Key Laboratory of Crop High Quality,Effective Cultivation and Safety Control in Yunnan Province,Honghe university,Mengzi 661100,China;2.School of Life Science,Yunnan University,Kunming 650091,China) |
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| Abstract: | The xanthine oxidoreductase plays an important role in the metabolism of purines,oxidizing hypoxanthine to xanthine and xanthine to uric acid.The enzyme features active sites composed of a single Mo atome coordinated by one molybdopterin-based ligand.In this paper the interaction models of the molybdopterin and ligands are reviewed according to the experimental and theoretical studies of the reactivity and structures of the xanthine oxidoreductase. |
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| Keywords: | xanthine oxidoreductase inhibitor substrate molybdenum cofactors molecular simulation |
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