Effect of vitamin E on the platelet xanthine oxidase and lipid peroxidation in the patients of myocardial infarction |
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| Authors: | Rashmi Raghuvanshi M Chandra P C Misra M K Misra |
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| Institution: | (1) Department of Biochemistry, University of Lucknow, 226007 Lucknow, India;(2) Department of Medicine, King George’s Medical College, Lucknow |
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| Abstract: | Platelets play important role in precipitating ischaemic myocardial syndromes in many ways. One of the consequences of ischaemic
diseases is excessive generation of oxygen derived free radicals that have numerous pathophysiological consequences. Platelet
pro-oxidant enzyme, xanthine oxidase is one of the sources of generation of free radicals. In the present paper, we report
the effect of administration of vitamin E along with aspirin on the levels of platelet xanthine oxidase and extent of free
radical mediated damage in the patients reperfused after myocardial infarction.
Our findings show that administration of 400 mg. vitamin E for six days along with 80 mg. aspirin has an excellent anti-oxidant
effect as evidenced by reduced platelet xanthine oxidase activity and lowering of malondialdehdye (MDA) levels which is an
index of the extent of free radical mediated damage. |
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| Keywords: | Vitamin E Platelets Myocardial infarction Xanthine oxidase Lipid peroxidation Aspirin |
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