| 鼻息肉上皮中血管活性肠肽和P物质表达的初步研究 |
| |
| 引用本文： | 薛刚,吴靖芳,尚小领,林彦涛,成日青.鼻息肉上皮中血管活性肠肽和P物质表达的初步研究[J].河北北方学院学报(医学版),2005,22(1):4-6. |
| |
| 作者姓名： | 薛刚 吴靖芳 尚小领 林彦涛 成日青 |
| |
| 作者单位： | 1. 河北北方学院附属第一医院耳鼻咽喉-头颈外科,075000
2. 河北北方学院组胚教研室 |
| |
| 基金项目： | 河北省卫生厅医学科研项目 |
| |
| 摘 要： | 目的:探讨人鼻息肉组织中SP和VIP的表达及意义.方法:采用HE染色、PAS染色和免疫组化方法检测人鼻息肉组织的病理变化及SP和VIP表达.结果:鼻息肉黏膜均有不同程度的改变,实验组与对照组相比基膜明显增厚(P＜0.01);A、C组差别显著(P＜0.05).实验组黏液腺面积与对照组相比差别显著(P＜0.01).SP和VIP免疫反应阳性结构均呈棕黄色,二者在实验组与对照组分布相似.SP阳性纤维分布于血管、腺体周围,可见散在的圆形或椭圆型阳性细胞,部分黏膜下腺体上皮细胞也呈SP阳性;但实验组阳性纤维和细胞明显稀疏.VIP阳性纤维和细胞位于黏膜腺体、血管周围以及部分黏膜上皮和黏膜下腺上皮细胞胞质中,但实验组中VIP阳性纤维着色较深,密度增加.结论:SP和VIP在鼻息肉形成中具有重要的作用.
|
| 关 键 词： | 鼻息肉 血管活性肠肽 P物质 组织化学 免疫组织化学 |
| 文章编号： | 1673-1484(2005)01-0004-03 |
Histochemical and Immunohistochemical Study of Chronic Sinusitis and Nasal Polyps |
| |
| XUE Gang,WU Jing-fang,SHANG Xiao-ling,et al..Histochemical and Immunohistochemical Study of Chronic Sinusitis and Nasal Polyps[J].Journal of Hebei North University:Medical Edition,2005,22(1):4-6. |
| |
| Authors: | XUE Gang WU Jing-fang SHANG Xiao-ling |
| |
| Institution: | XUE Gang,WU Jing-fang,SHANG Xiao-ling,et al.The First Affiliated Hospital,Hebei North University,Zhangjiakou,075000,China |
| |
| Abstract: | Objective: To investigate the expression and signi ficance of the SP and VIP in nasal polyp. Methods: The pathologicalcharacteristic and expression of the SP and VIP in nasal polyp were studiedby hematoxylin and eosin(HE),periodic acid schiff(PAS) and immunohistochemicalstaining method. Results: There were different changes in mucosain experiment group. The basement membrane was thickened as compared with control group(P<0.01). There were significant difference between group A and C ( P<0.05). The area of mucous glands experiment group were obviously increased compared with control group. The SP and VIP immunoreactive material were brown. They were similar between the control and experimentgroups. SP immunoreactive positive fiber were distributed near the vascular andgland. There were some positive cells shaped as round or ovoid, and epithelia of gland in submucosa . But there were less SP positive material in the experimentgroup. The VIP fibers and cells were mainly to be found in the close proximity tothe submucosal glands and fairly close to the vessels. The plasma in the part ofmucosa and submucosal glands epithelia were VIP immunoreactive positive. There werethicker color and higher density of VIP positive structure in experiment!group.Conclusion: SP and VIP might play significant roles in the patho genesis of nasal polyp. |
| |
| Keywords: | nasal polyp vasoactive intestinal peptide(VIP) substance P(SP) histochemistry immunohistochemistry |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
