| 串联aza-wittig反应合成2-芳氨基-3-氨基-5-苄基-1-咪唑啉-4-酮 |
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| 引用本文： | 许志锋,邝代治,张复兴,邓芹英.串联aza-wittig反应合成2-芳氨基-3-氨基-5-苄基-1-咪唑啉-4-酮[J].衡阳师范学院学报,2007,28(3):68-70. |
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| 作者姓名： | 许志锋 邝代治 张复兴 邓芹英 |
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| 作者单位： | 1. 衡阳师范学院化学与材料科学系,湖南,衡阳,421008
2. 中山大学,化学与化学工程学院,广州,510275 |
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| 基金项目： | 湖南省教育厅资助项目(04C136) |
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| 摘 要： | 由叠氮乙酸乙酯1与氯化苄反应,合成叠氮化合物2,2与三苯基膦发生Staudinger反应制得膦亚胺3,3与异氰酸苯脂、肼通过串连aza-Wittig反应合成了3个新的咪唑啉酮衍生物5 a~5 c。用元素分析、IR1、H NMR表征了它们的结构。发现碳二亚胺与肼加成反应后再生成咪唑啉酮环时具有一定的选择性。
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| 关 键 词： | 咪唑啉酮 合成 aza-Wittig反应 |
| 文章编号： | 1673-0313（2007）03-0068-03 |
| 收稿时间： | 2007-01-08 |
| 修稿时间： | 2007-01-08 |
Synthesis of 2-Arylamino-3-amino-5-benzyl-4H-imidazolin-4-ones by Tandem aza-Wittig Reaction |
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| XU Zhi-feng,KUANG Dai-zhi,ZHANG Fu-xing,DENG Qin-ying.Synthesis of 2-Arylamino-3-amino-5-benzyl-4H-imidazolin-4-ones by Tandem aza-Wittig Reaction[J].journal of Hengyang Normal University,2007,28(3):68-70. |
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| Authors: | XU Zhi-feng KUANG Dai-zhi ZHANG Fu-xing DENG Qin-ying |
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| Institution: | 1 . Department of Chemistry and Material Science , Hengyang Normal University, Hengyang Hunan 421008, China; 2. School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China |
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| Abstract: | The azide 2,obtained by the reaction of azidoethylacetate 1 and benzyl chloride,was allowed to take Staudinger reaction with triphenylphosphine to give iminophosphorane 3.The imidazolinone derivatives(5a~5c) were synthesized by a tandem aza-Wittig reaction of iminophosphorane 3 with aryl isocynate and hydrazine.The structures of the compounds synthesized were confirmed by elemental analysis,IR and 1H NMR.The cyclizing reaction of imidazolinones has a certain selectivity. |
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| Keywords: | imidazolinone synthesis aza-Wittig reaction |
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