| 安妥沙星晶体结构及荧光性能 |
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| 引用本文： | 葛裕华,孙会,王明亮.安妥沙星晶体结构及荧光性能[J].东南大学学报,2011(4):449-451. |
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| 作者姓名： | 葛裕华 孙会 王明亮 |
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| 作者单位： | 东南大学化学化工学院 |
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| 摘 要： | 以盐酸安妥沙星为原料,通过脱HC1反应制备了安妥沙星游离碱,在乙腈-甲醇混合溶剂中培养出单晶,经单晶X衍射测得其晶体结构属于三斜晶系,空间群为P1,晶胞参数:a=0.663 07(13) nm,b=0.898 39(18)nm,c=1.5690(3) nm;α =75.12(3)°,β=87.92(3)°,γ=77.5...
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| 关 键 词： | 安妥沙星 氟喹诺酮类 晶体结构 荧光性能 |
Crystal structure and fluorescence property of antofloxacin |
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| Ge YuhuaSun HuiWang Mingliang.Crystal structure and fluorescence property of antofloxacin[J].Journal of Southeast University(English Edition),2011(4):449-451. |
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| Authors: | Ge YuhuaSun HuiWang Mingliang |
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| Institution: | Ge YuhuaSun HuiWang Mingliang(School of Chemistry and Chemical Engineering,Southeast University,Nanjing 211189,China) |
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| Abstract: | Antofloxacin free base is prepared from antofloxacin hydrochloride by removing hydrogen chloride.Its crystal is obtained by slow evaporation of an acetonitrile-methanol mixed solution.Single-crystal X-ray diffraction reveals that the crystallography belongs to a triclinic P1-space group with cell parameters:a=0.66307(13) nm,b=0.89839(18) nm,c=1.5690(3) nm,α=75.12(3)°,β=87.92(3)°,γ=77.57(3)°.Antofloxacin shows no fluorescence in solution,but the crystalline state emits strong green light at 510 nm under the excitation of 360 nm,indicating a fluorescence enhancement induced by aggregation.It demonstrates that intermolecular packing and interaction in the crystal lead to the improved fluorescence quantum yield.These results provide important information for the further exploration of the structure-activity relationship of antofloxacin and the development of new drugs. |
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| Keywords: | antofloxacin flouroquinolones crystal structure fluorescence property |
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