Assessment of oxidative stress and antioxidant status in age related cataract in a rural population |
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| Authors: | A K Pradhan A K Shukla M V R Reddy N Garg |
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| Institution: | (1) Department of Biochemistry and J.B. Tropical Disease Research Centre, MGIMS, 442 102, Wardha, Sevagram, India;(2) Department of Ophthalmology, MGIMS, 442 102 Sevagram, Wardha, India |
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| Abstract: | Oxidative stress was assesed by estimating lipid peroxidation product (LPO) in the form of thiobarbituric acid reactive substances
(TBARS), enzymatic antioxidants in the form of superoxide dismutase (SOD), catalase and nonenzymatic antioxidant vitamins
e.g. vitamin C, β carotene and vitamin E in either serum or plasma or erythrocytes in 190 cases of age related cataract in
the age group of 50–80 years. 190 cases were grouped into three morphological types namely, 73 cases of cortical, 77 cases
of posterior subcapsular and 40 cases of nuclear cataract and values of LPO and antioxidants were compared with 78 cases of
age matched healthy control groups. Plasma TBARS levels were cataract cases when compared with control groups. There were
no significant differences in the erythrocyte levels of catalase and plasma levels of Vit E between cataract cases and control
groups. No significant changes of parameters were seen among three different morphological types of age related cataract.
The present study shows that the oxidative stress may play an important role in the age related cataract. |
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| Keywords: | Oxidative stress Lipid peroxidation product Antioxidant Age related cataract |
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