Urinary 8-OHdG: A marker of oxidative stress to DNA and total antioxidant status in essential hypertension with South Indian population |
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| Authors: | P Subash Prema Gurumurthy A Sarasabharathi K M Cherian |
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| Institution: | (1) Faculty of Pharmacy of Monastir, Unit of Research URSAM 03/UR/07-01, Street Ibn-Sina, 5000 Monastir, Tunisia;(2) Laboratory of Biochemistry, Hospital Ibn El Jazzar of Kairouan, 3100 Kairouan, Tunisia |
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| Abstract: | Establishment of non-invasive urinary biomarker for the early prediction of essential hypertension (EH) is important. We evaluated
whether estimation of urinary DNA, serves as a marker to predict the extent of cellular oxidative stress in essential hypertension.
A total of 180 South Indian subjects aged 30–65 were recruited for the study. Of these hypertensive subjects investigated,
30 were newly diagnosed and were not on any antihypertensive drugs, but had systolic blood pressure 140–160 mmHg and diastolic
blood pressure 95–100 mmHg and 75 hypertensive patients who already on drug therapy for one year and 75 were South Indian
normotensive healthy controls with blood pressure ≤ 120/80 mmHg. The 8-OHdG level in urine was significantly increased in
hypertensive patients (both newly diagnosed and who already on drug therapy) compared with control group. The significant
increase in 8-OHdG was observed in newly diagnosed hypertensive patients compared with hypertensive patients who already on
drug therapy. There was a significant decrease in serum TAS value in essential hypertensive group when compared to control
group. The urinary 8-OHdG was independently correlated with serum TAS. Decreased TAS levels, which reflect to increased oxidative
stress, may be the reason of increased urinary 8-OHdG in South Indian hypertensive patients. Our preliminary data suggest
that the competitive ELISA for 8-OHdG appears to be a simple method for quantifying the extent of oxidative stress. |
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