| 复方甘草酸苷联合拉米夫定治疗慢性乙型肝炎的临床研究 |
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| 引用本文： | 陈耀凯,王宇明,方蓉.复方甘草酸苷联合拉米夫定治疗慢性乙型肝炎的临床研究[J].大连大学学报,2006,27(4):31-34. |
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| 作者姓名： | 陈耀凯 王宇明 方蓉 |
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| 作者单位： | 第三军医大学西南医院,全军感染病研究所,重庆,400038 |
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| 基金项目： | 致谢：本研究得到深圳健安医药有限公司的大力支持,特致感谢! |
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| 摘 要： | 目的]观察复方甘草酸苷对慢性乙型肝炎患者血清病毒学标志的影响．方法]采用复方甘草酸苷联合拉米夫定治疗30例慢性乙肝患者,并与30例拉米夫定单药治疗患者比较,观察治疗后血清病毒学标志及肝功能指标的变化．结果]治疗12周时联合治疗组血清HBeAg／抗-HBe转换率明显高于对照组；治疗12周和24周时联合治疗组肝功能指标复常率明显高于对照组．结论]复方甘草酸苷治疗慢性乙型肝炎可能有助于患者在拉米夫定治疗过程中早期发生HBeAg／抗-HBe血清转换．
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| 关 键 词： | 复方甘草酸苷 慢性乙型肝炎 拉米夫定 |
| 文章编号： | 1008-2395（2006）04-0031-04 |
| 收稿时间： | 2006-06-14 |
| 修稿时间： | 2006年6月14日 |
Combination treatment of chronic hepatitis B with stronger neo-minophagen C (SNMC) and lamivudine |
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| CHEN Yao-kai,WANG Yu-ming,FANG Rong.Combination treatment of chronic hepatitis B with stronger neo-minophagen C (SNMC) and lamivudine[J].Journal of Dalian University,2006,27(4):31-34. |
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| Authors: | CHEN Yao-kai WANG Yu-ming FANG Rong |
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| Abstract: | Objective] To observe the effects of stronger neo-minophagen C ( SNMC ) on HBV virological markers in patients with chronic hepatitis B. Methods] Sixty patients with chronic hepatitis B were included in this stud-y. Thirty of them were treated with SNMC and lamivudine concomitantly, and the others were treated with lamivudine only. The HBV markers and liver function parameters were monitored during the treatment. Results] HBeAg/ anti-HBe seroconversion rate was significantly higher in the combination group than in the controls after 12 weeks' treatment. The normalization for liver function parameters were significantly higher in the combination group than in the controls after 12 weeks' and 24 weeks' treatment. Conclusions] SNMC treatment may be helpful to HBeAg/ anti-HBe seroconversion in chronic hepatitis B patients when combined with lamivudine. |
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| Keywords: | stronger neo-minophagen C chronic hepatitis B lamivudine |
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