Correlation Between Proinflammatory Serum Markers: High Sensitivity C-Reactive Protein,Interleukin-6 with Disability Score in Acute Ischemic Stroke |
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| Authors: | Anuradha Bharosay Kiran Saxena Meena Varma Vivek Vikram Bharosay Aparna Pandey |
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| Institution: | (1) Department of Biochemistry, Sri Aurobindo Institute of Medical Sciences, Indore, MP, 452001, India;(2) College of Medical Sciences, Amargarh, District Bhavnagar, Indore, MP, India;(3) Department of Pathology, Sri Aurobindo Institute of Medical Sciences, Indore, MP, India;(4) C/O Mr Sudhir Raizada, 95, Geeta Nagar, Opposite Shishukunj School, Indore, MP, 452001, India |
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| Abstract: | Stroke being the third leading cause of death and foremost cause of disability, if potential diagnostic utility of blood borne
protein biomarkers in predicting acute stroke is established, it would be a substantial adjunct to computerized tomography
and magnetic resonance imaging which have their own limitations. This study was done to correlate serum Interleukin 6, high
sensitivity C reactive protein at the time of admission with neurological worsening assessed by NIHSS at the time of admission
and 7 days after admission. 46 Patients admitted in neurology department SAIMS, Indore with first ever ischemic stroke within
72 h of onset were included in the study. All patients with history of stroke of more than 72 h onset, Infection & peripartum
stroke were excluded from the study. Disability scoring was done by NIHSS and their serum samples assayed for hsCRP, IL6 by
commercially available quantitative sandwich enzyme-linked immunoadsorbent assay kits. Serum samples of 50 control cases which
included healthy volunteers and staff from SAIMS were also analyzed for hsCRP, IL6 for comparative study. A significant correlation
was observed between NIHSS scoring and serum hsCRP and IL6 at the time of admission. Patients with initial high serum IL6
and hsCRP also showed significant clinical deterioration as assessed by NIHSS scoring 7 days after admission. Elevated hsCRP
and IL6 within 72 h of admission strongly correlated with functional disability in study population in India and may serve
as useful adjunct to CT Scan in emergency setting. |
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| Keywords: | Ischemic stroke High sensitive C-Reactive Protein Interleukin-6 National Institute of Health Stroke Scale Disability score |
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