| D-半乳糖对小鼠脾淋巴细胞功能的影响 |
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| 引用本文： | 冯明功,李建,刘玉凤.D-半乳糖对小鼠脾淋巴细胞功能的影响[J].大连大学学报,2000,21(2):80-82. |
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| 作者姓名： | 冯明功 李建 刘玉凤 |
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| 作者单位： | 大连大学医学院!辽宁大连116622，大连市结核病医院!辽宁大连116622，吉林安图县医院!吉林，安图133600 |
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| 摘 要： | 目的：探讨Ｄ－半乳糖（Ｄ－Ｇａｌ）对小鼠脾淋巴细胞损伤的分子机理．方法：测定不同浓度Ｄ－Ｇａｌ作用后小鼠淋巴细胞乳酸脱氢酶（ＬＤＨ）、超氧化物歧化酶 （ＳＯＤ）、琥珀酸脱氢酶（ＳＤＨ）活性以及过氧化脂质（ＬＰＯ）水平．结果：与对照组比较，ＬＤＨ、ＳＯＤ和ＳＤ Ｈ活性均有显著降低（Ｐ＜０．０１），ＬＰＯ水平显著提高（Ｐ＜０．０１）．结论：Ｄ－Ｇａｌ能引起小鼠脾淋巴细胞及其功能的损伤．
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| 关 键 词： | D-半乳糖 脾淋巴细胞 SOD LPO SDH |
The Effect of D-Galactose on Splenolymphocytes and its Function of Mice |
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| FENG Ming-gong,et al.The Effect of D-Galactose on Splenolymphocytes and its Function of Mice[J].Journal of Dalian University,2000,21(2):80-82. |
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| Authors: | FENG Ming-gong |
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| Abstract: | Object To discuss the molecule mechanism of damage on mouse splenolymphocytes by D -galactose(D-Gal). Method The mouse spleen cells were cultivated with different density of D-Gal in vitro. Results As Compared with the control group, Lactate dehydrogenase (LDH) activity. Superoxide Dismutase (SOD) activity and Succinate dehydrogenase(SDH) of D -Gal group decreased distinctly, however, Lipid Peroxyl (LPO) increased distinctly. Conclusion D -Gal can cause peroxidate damage of mouse spleen lymphocyte and its function. |
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| Keywords: | D-galactose splenolymphocytes SOD LPO SDH |
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