Levels of cerebrospinal fluid and serum acetylcholinesterase in Tuberculous and pyogenic meningitis in children |
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| Authors: | K N Dave B N Dave F R Billimoria M N Mehta |
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| Institution: | 1. Department of Paediatrics, LTMM College & LTMG Hospital, Sion, 400 022, Bombay
3. Department of Biochemistry, LTMM College & LTMG Hospital, Sion, 400 022, Bombay
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| Abstract: | Total acetylcholinesterase activity (AChE) was estimated in CSF and serum of 163 cases, comprising of 64 cases of Tuberculous
meningitis (TBM), 60 cases of pyogenic meningitis (PM) and 30 control in the paediatric age group. Mean CSF-AChE levels were
7.94±0.38, 9.06±0.16 and 9.80±0.30 unit/ml (Mean±S.E.) in Control, TBM and PM respectively. The respective serum AChE levels
were 2.65±0.13, 3.18±0.07 and 3.93±0 0.035 units/ml. The ratio of CSF/serum-AChE in three groups were 3.09±0.137 (Mean±S.E.),
2.88±0.087, 2.98±0.092 in control, TBM and PM respectively. The values in both CSF as well as in serum in patient with TBM
and in PM were significantly higher as compared to controls. However, the differences between the mean CSF-AChE and serum-AChE
levels and CSF-AChE/serum-AChE were insignificant. Thus, though AChE levels are raised in meningitis, they are not helpful
in differentiating TBM from PM. |
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