| 三碘苯酚乙基纤维素微球的制备 |
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| 作者姓名： | 刘瑞丽 姜庆军 刘士远 李文新 |
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| 作者单位： | 1. 中国科学院上海应用物理研究所, 上海 201800;
2. 第二军医大学, 上海 200433 |
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| 摘 要： | 为提高造影剂的颗粒度,减少血池造影剂透过血管壁向组织间质渗出,影响血池造影剂的造影效果,采用液中干燥法制备了三碘苯酚乙基纤维素微球,研究了三碘苯酚与乙基纤维素的质量比对微球成球性、粒径以及载药量的影响,发现两者的质量比为1∶2时成球性最好,所得微球为规整的球形,微球粒径最小,平均粒径D50为3.68μm,载药量为41.4%.
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| 关 键 词： | 液中干燥法 三碘苯酚 乙基纤维素微球 血池造影剂 |
| 收稿时间： | 2004-07-26 |
| 修稿时间： | 2004-10-14 |
Development of 2,4,6-Triiodophenol Microspheres with Ethylcellulose |
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| Authors: | LIU Rui-Li JIANG Qing-Jun LIU Shi-Yuan LI Wen-Xin |
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| Institution: | 1. Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China;
2. Second Military Medical University, Shanghai 200433, China |
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| Abstract: | In this paper,2,4,6-triiodophenol-ethylcellulose microsphere was developed by in2liquid drying method, in order to increase the granularity of the X2ray CT contrast agent and to prevent the blood vessel X-ray CT contrast agent from exuding through the vascular wall to the tissue. The influences of the composition ratio of 2,4,6-triiodophenol : ethylcellulose to the microspheres ’ appearance and diameter, and the entrapment of 2,4,6-triiodophenol were studied. It was found that when the composition ratio was 1∶2, the microspheres’ appearance was round, the average diameter was only 3168μm, and the entrapment of 2,4,6-triiodophenol was 4114 %. |
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| Keywords: | in-liquid drying method 2 4 6-triiodophenol ethylcellulose microsphere blood vessel X-ray CT contrast agent |
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