| 碳纤维增强型树脂基复合材料的生物安全性评价 |
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| 引用本文： | 刘丽,高燕,张烈焚.碳纤维增强型树脂基复合材料的生物安全性评价[J].科技通报,2005,21(6):693-696. |
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| 作者姓名： | 刘丽 高燕 张烈焚 |
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| 作者单位： | 浙江大学,附属口腔医院,杭州,310031 |
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| 基金项目： | 浙江省科技厅资助(021102002) |
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| 摘 要： | 目的评价碳纤维增强型树脂基复合材料(CFRP)的生物相容性,为其在口腔临床中的应用提供依据。方法本研究进行三种体内外试验,即短期全身毒性试验(经口途径),静脉注射急性全身毒性试验和溶血试验。结果实验一:对照组和试验组大鼠均未出现毒性反应,对照组和实验组的体重增长率和食物利用率无明显差异(P>0.05),肉眼观察动物重要脏器,均未出现病理变化;实验二:对照组和试验组小鼠均未出现毒性症状,试验组和对照组小鼠体重无明显差异(P>0.05);实验三:测的体外溶血率2%。结论碳纤维增强型树脂基复合材料对动物无全身毒性作用也无溶血作用。
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| 关 键 词： | 碳纤维 生物相容性 短期全身毒性试验(经口途径) 静脉注射急性全身毒性试验 溶血试验 |
| 文章编号： | 1001-7119（2005）06-0693-04 |
| 收稿时间： | 2005-05-23 |
| 修稿时间： | 2005年5月23日 |
Evaluation of Biological Safety of Carbon-Fibre Reinforced Resin Compound |
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| LIU Li,GAO Yan,ZHANG Lie-fen.Evaluation of Biological Safety of Carbon-Fibre Reinforced Resin Compound[J].Bulletin of Science and Technology,2005,21(6):693-696. |
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| Authors: | LIU Li GAO Yan ZHANG Lie-fen |
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| Institution: | School of Stomotology, Zhejiang University, Hangzhou 310031, China |
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| Abstract: | Purpose To evaluate the biological safety of carbon-fibre reinforced composite as a dental material and provide the evidence before clinical applicati on.Methods Three tests were chosen in this study,namely short-term systemic tox icity(oral route),acute systemic toxicity test(introvenous route) and haemolys is test.Results Test 1.None of the rats was abnormal,there was no significant differencs in utility rate of forage and relative rising rate of weight between the experimental group ang control group(P>0.05).The internal organs had no pat hological change.Test 2.All mice had no toxic sign,there was no significant difference in the change of weight between the experiment group and control group( P>0.05).No pathological change was found in the internal organs.Test 3.Acute ha emolysis rate in vitro of the material was 2%.Conclusion Carbon-fibre reinforced resin compound had no acute systemic toxic action on animals and haemolysis effect in vitro. |
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| Keywords: | carbon-fibre short-term systemic toxicity(oral route) acute systemi ctoxicity test(introvenous route) haemolysis |
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