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| 昆虫中类胰岛素肽保守的信号系统和生理学功能 | |
| 引用本文： | 吴琦,赵宏媛,文铁桥.昆虫中类胰岛素肽保守的信号系统和生理学功能[J].上海大学学报(英文版),2004,8(2):227-234. |
| 作者姓名： | 吴琦 赵宏媛 文铁桥 |
| 作者单位： | [1]DepartmentofCellularBiotoggandBiomedicalandHealthSciencesInstitute,UniversityofGeorgia,Athens,GA30602,USA [2]SchoolofVeterinaryMedicine,UniversityofGeorgia,Athens,GA30602,USA [3]LaboratoryofNeuralMolecularBiology,SchoolofLifeSciences,ShanghaiUniversity,Shanghai200436,P.R.China |
| 摘 要： | Insulin is one of the most extensively studied protein hormones, and its structure and function have been elucidated in many vertebrate species, ranging from human to fish. Insulin-like peptides (ILPs) also have been found and characterized in different invertebrates, including nematodes, mollusks and insects. However, insect ILPs turned out to be a structurally diverse group encoded by large multi-gene families that are expressed in the brain and other tissues and serve functions different from vertebrate insulin. Recent physiological and genetic studies have revealed that, in different insect species, the conserved insulin signaling pathway plays a key role in the regulation of a variety of fundamental processes, such as metabolism, growth, reproduction and aging. Here, the structures, distributions, conserved signaling pathways, and physiological functions of insect ILPs are reviewed in detail. |
| 关 键 词： | 昆虫 类胰岛素肽 保守信号系统 生理学功能 老化 生长 接收器 再生 |
| 收稿时间： | 16 October 2003 |
The conserved signaling pathways and physiological functions of insulin-like peptides in insects |
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| Wu Qi,Zhao Hong-yuan,Wen Tie-qiao.The conserved signaling pathways and physiological functions of insulin-like peptides in insects[J].Journal of Shanghai University(English Edition),2004,8(2):227-234. | |
| Authors: | Wu Qi Zhao Hong-yuan Wen Tie-qiao |
| Institution: | 1. Department of Cellular Biology and Biomedical and Health Sciences Institute, University of Georgia, Athens, GA 30602, USA 2. School of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA 3. Laboratory of Neural Molecular Biology, School of Life Sciences, Shanghai University, Shanghai 200436, P. R. China |
| Abstract: | Insulin is one of the most extensively studied protein hormones, and its structure and function have been elucidated in many vertebrate species, ranging from human to fish. Insulin-like peptides (ILPs) also have been found and characterized in different invertebrates, including nematodes, mollusks and insects. However, insect ILPs turned out to be a structurally diverse group encoded by large multi-gene families that are expressed in the brain and other tissues and serve functions different from vertebrate insulin. Recent physiological and genetic studies have revealed that, in different insect species, the conserved insulin signaling pathway plays a key role in the regulation of a variety of fundamental processes, such as metabolism, growth, reproduction and aging. Here, the structures, distributions, conserved signaling pathways, and physiological functions of insect ILPs are reviewed in detail. |
| Keywords: | aging cell size growth metabolism receptor reproduction |
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