| rhEPO和睾酮对低氧小鼠血清ASTase、ALTase、LDHase活性抑制效应 |
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| 引用本文： | 孟庆瑜,孟宪法,姜如冈.rhEPO和睾酮对低氧小鼠血清ASTase、ALTase、LDHase活性抑制效应[J].大连大学学报,2000,21(4):82-84,87. |
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| 作者姓名： | 孟庆瑜 孟宪法 姜如冈 |
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| 作者单位： | 大连大学医学院!辽宁大连 116622，大连大学医学院!辽宁大连 116622，天津医科大学!天津 300070 |
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| 基金项目： | 辽宁省教委高等学校科学研究项目!（9649311284） |
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| 摘 要： | 目的观察ｒｈＥＰＯ和睾酮对低氧小鼠血清ＡＳＴａｓｅ、ＡＬＴａｓｅ、ＬＤＨａｓｅ活性的影响．方法应用低压舱小鼠实验（０．４２ａｔｍ，２２ｈ／ｄ， ６ｄａｙｓ），分别注射ｒｈＥＰＯ（２００ｕ／ｋｇ·ｄ）、宰酮（２．５ ｍｇ／ｄ）、皮质醇（０．５ ｍｇ／ｄ），检测血清酶活性、血清 ＥＰＯ浓度和 Ｈｃｔ．结果ｒｈＥＰＯ和睾酮不同程度地抑制低氧小鼠血清酶活性．结论ｒｈＥＰＯ和睾酮对低氧动物肝功能具有不同程度地保护效应。
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| 关 键 词： | 促红细胞生成素(EPO) 睾酮 血清酶 肝功能 低氧 |
Inhibitory Effects of rhEPO and Testosterone on Serum ASTase, ALTase, LDHase Activity in Mice with Hypoxia |
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| MENG Qing- yu,MENG Xian- fa,JIANG Ru- gang.Inhibitory Effects of rhEPO and Testosterone on Serum ASTase, ALTase, LDHase Activity in Mice with Hypoxia[J].Journal of Dalian University,2000,21(4):82-84,87. |
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| Authors: | MENG Qing- yu MENG Xian- fa JIANG Ru- gang |
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| Abstract: | Objective: To explore the effects of rhEPO and testosterone on serum ASTase, ALTase, LDHase enzyme activity in mice with hypoxia. Methods: The experimental model of mice was established to be exposed to hypobaric chamber(0.42atm, 22h/d) over a 6 days period, injected by rhEPO (200u/kg· d), testosterone (2.5mg/d) cortisol (0.5mg/d) respectively and examined serum enzyme activity, serum EPO and hematocrit. Results: The inhibitory effects of rhEPO and testosterone on serum enzyme activity were occurred in mice with hypoxia stress continuously. Conclusions: The protective effect on liver function by administered rhEPO or testosterone in mice with hypoxia. |
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| Keywords: | erythropoietin testosterone serum enzyme liver function hypoxia |
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