Oxidative injury and antioxidant vitamins E and C in Schizophrenia |
| |
| Authors: | Benedicta D'Souza Vivian D'Souza |
| |
| Institution: | (1) Department of Biochemistry, Center for Basic Sciences, Kasturba Medical College, Bejai, 575004 Mangalore, India |
| |
| Abstract: | Susceptibility of Schizophrenic patients to lipid peroxidation relative to healthy control subjects was investigated by measuring
the malondialdehyde (MDA) levels in plasma. The main finding was that Schizophrenic patients were more susceptible than control
subjects to oxidative damage as evident from increased MDA levels in plasma. Antioxidant levels are also depleted in Schizophrenic
patients when compared to normal subjects as evident from decreased levels of vitamins E and C in the plasma. Impaired antioxidant
defense and increased lipid peroxidation suggests that treatment with antioxidants (Vitamin E, Vitamin C, beta carotene) at
the initial stages of illness may prevent further oxidative injury and deterioration of associated neurological deficits in
Schizophrenia. |
| |
| Keywords: | Lipid peroxidation antioxidant vitamins E & C Schizophrenia |
| 本文献已被 SpringerLink 等数据库收录！ |
