| Association of Graves’ disease and Graves’ ophthalmopathy with the polymorphisms in promoter and exon 1 of cytotoxic T lymphocyte associated antigen-4 gene |
| |
| 作者姓名： | ZHANG Qin YANG Yun-mei LV Xue-ying |
| |
| 作者单位： | Department of Very Important People，the First Affiliated Hospital，School of Medicine，Zhejiang University，Hangzhou 310003，China |
| |
| 摘 要： | INTRODUCTION Graves’ disease (GD) is an autoimmune diseasecharacterized clinically by hyperthyroidism, diffusegoiter, Graves’ ophthalmopathy (GO) and the pres-ence of TSH (thyroid-stimulating hormone) receptorautoantibodies. GD is a multifactorial disease thadevelops as the result of a complex interaction be-tween genetic susceptibility genes and environmentafactors. Multiple genetic factors are believed to in-fluence the autoimmunity evident in GD, but a firmgenetic basis for GD …
|
| 关 键 词： | Graves’ ophthalmopathy Cytotoxic T lymphocyte associated antigen-4 (CTLA-4) gene Gene frequency Susceptibility gene |
| 本文献已被 CNKI 等数据库收录！ |
