| 抗肿瘤药物Combretastatin A-4的简便合成 |
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| 引用本文： | 刁银军,周晓莺.抗肿瘤药物Combretastatin A-4的简便合成[J].金华职业技术学院学报,2010,10(3):57-60. |
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| 作者姓名： | 刁银军 周晓莺 |
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| 作者单位： | 1. 金华职业技术学院,浙江,金华,321007
2. 义乌工商学院,浙江,义乌,322000 |
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| 基金项目： | 浙江省科技厅计划项目，浙江省教育厅科研计划项目 |
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| 摘 要： | 采用固相Wittig反应合成抗肿瘤药物Combretastatin A-4。以溴化三甲氧基苄基三苯基鏻与3-三苯氧基异香兰素为原料,经缩合、脱保护等反应合成Combretastatin A-4。目标化合物经核磁共振氢谱、熔点等确证其化学结构,总收率均达到62%左右。该路线反应条件简便,步骤较短,对顺式产物选择性高。
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| 关 键 词： | 固相wittig反应 立体选择 Combretastatin A-4 |
Convenient Synthesis of Anticancer Agent Combretastatin A-4 |
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| DIAO Yin-jun,ZHOU Xiao-ying.Convenient Synthesis of Anticancer Agent Combretastatin A-4[J].Journal of Jinhua College of Profession and Technology,2010,10(3):57-60. |
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| Authors: | DIAO Yin-jun ZHOU Xiao-ying |
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| Institution: | 1.JinHua College of Vocation and Technology,Jinhua 321007,China;2.YiWu Industrial and Commercial College,YiWu 322000,China) |
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| Abstract: | To synthesize the anticancer agent Combretastatin A-4,iso-vanilline and 3,4,5-trimethoxybenzyltriphenylphosphonium were used as starting materials via solid phase Wittig reaction to prepare Combretastatin A-4.The structures of target compounds were confirmed by 1H NMR and melting point.The overall yields were about 62%.The synthetic routes developed herein require simple reaction conditions and few steps,and high stereoselectivity of cis-form production. |
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| Keywords: | Combretastatin A-4 |
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