| 帕金森病的非运动症状的临床研究 |
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| 引用本文： | 许丹芸.帕金森病的非运动症状的临床研究[J].科技通报,2012,28(2):29-31. |
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| 作者姓名： | 许丹芸 |
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| 作者单位： | 武警安徽省总队医院神经内科,合肥,230041 |
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| 摘 要： | 目的:研究帕金森病(PD)非运动症状(NMS)发生和分布特点及其美多巴治疗后的变化,为早期诊断、病情进展和预后评估及治疗提供依据.方法:对PD组和对照组行NMS问卷调查,给予美多巴治疗3个月,依据统一帕金森病评分量表、简易精神状态检查、汉密尔顿抑郁量表、匹兹堡睡眠质量指数、便秘问题量表评估对照.结果:PD组出现记忆下降、便秘、情绪下降、感觉下降等与对照组相比具有显著差异(P＜0.05),而头晕、失眠、泌尿系症状两组间无显著差异(P＞0.05).其中以记忆下降发生率最高,其次为便秘、注意力下降、汗多、流涎；美多巴对改善NMS亦有一定的疗效.结论:(1)NMS存在于PD各期,其中以记忆下降发生率最高；(2)美多巴对改善NMS亦有一定疗效.
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| 关 键 词： | 帕金森病 非运动症状 记忆障碍 |
Parkinson's Disease of the Non Motor Symptoms in Clinical Research |
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| XU Danyun.Parkinson's Disease of the Non Motor Symptoms in Clinical Research[J].Bulletin of Science and Technology,2012,28(2):29-31. |
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| Authors: | XU Danyun |
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| Institution: | XU Danyun (Anhui Provincial Armed Police Corps Hospital nerve internal medicine,Hefei 230041,China) |
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| Abstract: | Objective,To explore the incidence and its distribution of NMS in PD patients and after treatment,to provide a basis for early diagnosis,progression and prognosis and therapeutic.Methods,An NMS questionnaires survey was performed in PD patients and control group.Madopar treatment for 3 months,according to the UPDRS,MMSE,HDRS,PSI,CPS for assessment of NMS.Results,PD group appeared memory drops,constipation,mood,feeling decline,compared with the normal group with significant difference(P < 0.05),dizziness,insomnia,urinary symptoms,appeared there are no significant differences(P > 0.05);the incidence of memory impairment is the highest,relatively high incidence constipation,attention drops,sweat,salivation;Madopa for treatment of NMS have a certain effect.Conclusion,(1)NMS are more commonly occurred throughout the stages of PD,the incidence of memory impairment is the highest.(2) Madopar on improvement of NMS have a certain effect. |
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| Keywords: | parkinson’s disease non-motor symptoms emory impairment |
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