| 阿维菌素缓释固体分散体的制备及其性能研究 |
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| 引用本文： | 姜官鑫,沈国清,朱鸿林,唐雯佳,赏国锋,王亭亭.阿维菌素缓释固体分散体的制备及其性能研究[J].科技通报,2012,28(5):125-129. |
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| 作者姓名： | 姜官鑫 沈国清 朱鸿林 唐雯佳 赏国锋 王亭亭 |
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| 作者单位： | 上海交通大学农业与生物学院,农业部都市农业(南方)开放重点实验室,上海,200240 |
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| 基金项目： | 国家自然科学基金，公益性行业(农业)科研专项，上海市科委科技攻关项目，上海市科技兴农推广项目 |
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| 摘 要： | 以聚乙二醇6000为载体,用熔融法制备了阿维菌素缓释固体分散体,并对其缓释性能和防紫外光降解作用进行了研究。结果表明,所制备的缓释固体分散体中,聚乙二醇6000对阿维菌素具有良好的包埋作用,包埋率可达94.23%~99.52%;阿维菌素的释放量随着温度的上升而上升,并具有良好的防紫外光降解的作用,其累积释放动力学方程为ARP=-91.6716 e-0.1022 t+98.1953,符合一级动力学释放模型。
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| 关 键 词： | 阿维菌素 固体分散体 缓释性能 聚乙二醇6000 |
Preparation and Properties of Controlled Release Solid Dispersion of Avermectin |
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| JIANG Guanxin
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SHEN Guoqing
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ZHU Honglin
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TANG Wenjia
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SHANG Guofeng
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WANG Tingting.Preparation and Properties of Controlled Release Solid Dispersion of Avermectin[J].Bulletin of Science and Technology,2012,28(5):125-129. |
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| Authors: | JIANG Guanxin SHEN Guoqing ZHU Honglin TANG Wenjia SHANG Guofeng WANG Tingting |
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| Institution: | (College of Agriculture and Biology,Shanghai Jiao Tong University; Key Laboratory of Urban(South),Ministry of Agriculture,Shanghai 200240,China) |
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| Abstract: | Controlled release solid dispersion of avermectin was prepared with Polyethylene glycol(PEG6000)as carriers by melting method.The release profiles and UV-shielding properties of the controlled release solid dispersion of avermectin were studied.The results indicated that avermectin was encapsulated by carriers PEG6000.The encapsulation efficiencies were 94.23%~99.52%.The release contents of controlled solid dispersion was increased with the temperature rise.The accumulative release corresponded with first order kinetics model.The kinetics equation was ARP=-91.6716 e-0.1022 t +98.1953.The UV-shielding properties of the controlled solid dispersion were also favorable. |
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| Keywords: | Avermectin solid dispersion release profiles polyethylene glycol 6000 |
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