| 耐力训练下调的HDMCP 表达对非酒精性脂肪肝线粒体活性氧
生成的影响 |
| |
| 引用本文： | 刘艳环,马国栋.耐力训练下调的HDMCP 表达对非酒精性脂肪肝线粒体活性氧
生成的影响[J].天津体育学院学报,2010,25(2):154-157. |
| |
| 作者姓名： | 刘艳环 马国栋 |
| |
| 作者单位： | 山东理工大学,体育学院,淄博255049 |
| |
| 基金项目： | 山东理工大学博士启动基金资助项目 |
| |
| 摘 要： | 目的:研究耐力训练对非酒精性脂肪肝HDMCP表达的影响及与活性氧生成的关系.方法:以西方膳食诱导的脂肪肝小鼠为模型,跑台运动为训练手段,测定肝脏HDMCP及MnSOD表达,顺乌头酸酶和MnSOD活性,MDA、OH·-含量的变化.结果:非酒精性脂肪肝小鼠模型组肝脏MnSOD与HDMCP表达显著升高,顺乌头酸酶活性显著下降,MnSOD活性显著升高,MDA和OH·-含量显著升高;耐力训练后MnSOD表达进一步升高,而HDMCP表达显著降低,顺乌头酸酶活性得到明显恢复,MDA和OH·-含量显著降低,MnSOD活性进一步升高.结论:HDMCP在非酒精性脂肪肝发病过程中可能作为一种应激蛋白,调控线粒体活性的生成,但其调控作用不能够完全代替抗氧化系统的作用,只是起辅助作用,抗氧化系统才是真正的抗氧化主体;耐力训练后,抗氧化系统能力进一步增强,HDMCP表达降低,从而提高线粒体偶联程度,增强线粒体ATP合成能力.
|
| 关 键 词： | 耐力训练 非酒精性脂肪肝 活性氧 肝细胞癌下调的线粒体转运蛋白 |
The Effect of Endurance Training Induced Downregulation of HDMCP on Mitochondrial Reactive Oxygen
Species Production in NAFLD Mice |
| |
| LIU Yanhuan,MA Guodong.The Effect of Endurance Training Induced Downregulation of HDMCP on Mitochondrial Reactive Oxygen
Species Production in NAFLD Mice[J].Journal of Tianjin Institute of Physical Education,2010,25(2):154-157. |
| |
| Authors: | LIU Yanhuan MA Guodong |
| |
| Institution: | LIU Yanhuan,MA Guodong (School of PE,Sh,ong University of Technology,Zibo 255049,China) |
| |
| Abstract: | Objective: To investigate the effect of endurance training on HDMCP expression and its impact on mitochondrial reactive oxygen species production in NAFLD. Methods: It analysised the expression of HDMCP and MnSOD and the changes of aconitase activity, MnSOD activity, contents of MDA and OH.- in liver in western diet-induced NAFLD of apoE knockout mice after 12 week treadmill endurance training. Results: Western diet significantly increased expression of HDMCP and MnSOD in liver. Aconitase activity decreased... |
| |
| Keywords: | endurance training non-alcoholic fatty liver disease reactive oxygen species HCC-down-regulated mitochondrial carrier protein |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《天津体育学院学报》浏览原始摘要信息 |
| 点击此处可从《天津体育学院学报》下载免费的PDF全文 |
|
