Uric acid a better scavenger of free radicals than vitamin C in rheumatoid arthritis |
| |
| Authors: | Mridula Mahajan Sukhraj Kaur Shruti Mahajan Ravi Kant |
| |
| Institution: | (1) Department of Biochemistry, Govt. Medical College, Amritsar, Punjab, India;(2) Department of Medicine, Govt. Medical College, Amritsar, Punjab, India;(3) E.S.I. Hospital, Amritsar, Punjab, India;(4) 100 Dayanand Nagar, Lawrence Road, Amritsar, Punjab, India |
| |
| Abstract: | Uric acid an endogenous aqueous antioxidant in normal humans is present in much higher concentrations than vitamin C and has
been known to cover 2/3rd of the free radical scavenging capacity in plasma. In the present study average uric acid levels of patients of rheumatoid
arthritis were found to be close to the normal individuals. A unique feature was observed after classifying the patients on
the basis of the duration of suffering, the patients having longer duration of disease had least uric acid levels as compared
to those suffering from relatively lesser period, similar trend was observed in the ascorbic acid estimations. The decline
in uric acid values with progression of the disease was much more than what was observed in case of ascorbic acid suggesting
the significant role of uric acid in scavenging of free radicals. Too much lowering of Uric Acid should be checked and vitamin
C should be supplemented in diet for maintaining the balance between pro oxidant and antioxidant forces to check pro oxidant
insult in rheumatoid arthritis. |
| |
| Keywords: | Inflammation Adenosine Deaminase Uric acid Rheumatoid Arthritis |
| 本文献已被 SpringerLink 等数据库收录！ |
|
