| 从HIF-2a基因中筛选评价HiHiLo训练中左心室功能效果的分子遗传学标记 |
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| 引用本文： | 金溪,胡扬,罗冬梅,李燕春,衣龙彦.从HIF-2a基因中筛选评价HiHiLo训练中左心室功能效果的分子遗传学标记[J].体育科学,2010,30(4). |
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| 作者姓名： | 金溪 胡扬 罗冬梅 李燕春 衣龙彦 |
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| 作者单位： | 北京体育大学,北京,100084 |
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| 摘 要： | 目的:通过对HIF-2a/EPAS1基因多态性与HiHiLo训练前后左心室功能指标进行关联分析,以期从HIF-2a/EPAS1基因多态位点中筛选评价HiHiLo训练中左心室功能效果的分子遗传学标记.方法:对72名健康受试者进行4周的HiHiLo训练,在实验前后测量左心室功能指标;采用PCR-RFLP方法对HIF-2a/EPAS1基因多态位点进行解析;对HIF-2a/EPAS1基因多态性与HiHiLo训练前后左心室功能指标进行关联分析,探寻HiHiLo训练中评价左心室功能效果的分子遗传学标记.结果:150 W负荷时,rs13419896 EDV变化量存在显著性差异(P<0.05),rs6715787 ESV变化量存在显著性差异,EF变化量具有极显著性差异(P<0.01);恢复状态下,rs6715787 EF变化量存在极显著性差异.结论:HIF-2a/EP-AS1基因rsl3419896多态位点与HiHiLo训练前后150 W时EDV相关联,提示可以作为大强度运动时EDV的HiHiLo训练左心室功能效果的分子遗传学标记;HIF-2a/EPAS1基因rs6715787多态位点与HiHiLo训练前后150 W时ESV和EF、恢复过程EF相关联,提示可以作为大强度运动时ESV和EF、恢复过程EF的HiHiLo训练左心室功能效果的分子遗传学标记.
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| 关 键 词： | 高住高练低训 低氧诱导因子2基因 分子遗传学标记 左心室功能 |
Selecting Molecular Genetic Markers for Evaluating the Effect of Cardiac Function in HiHiLo from HIF-2a Gene |
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| JIN Xi,HU Yang,LUO Dong-mei,LI Yan-chun,YI Long-yan.Selecting Molecular Genetic Markers for Evaluating the Effect of Cardiac Function in HiHiLo from HIF-2a Gene[J].China Sport Science,2010,30(4). |
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| Authors: | JIN Xi HU Yang LUO Dong-mei LI Yan-chun YI Long-yan |
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| Institution: | JIN Xi,HU Yang,LUO Dong-mei,LI Yan-chun,YI Long-yan Beijing Sport University,Beijing 100084,China. |
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| Abstract: | Purpose:Through making association study between HIF-2a/EPAS1 gene polymorphism and the function indexes of heart which are measured before and after HiHiLo,this paper investigates the molecule genetics markers from the HIF-2a/EPAS1 polymorphic sites.Methods:72 subjects with good health taking part in HiHiLo for 4 weeks,and they are measured cardiac function indexes.HIF-2a/EPAS1 gene polymorphic sites are analyzed by using PCR-RFLP.Association study is made between HIF-2a/EPAS1 gene polymorphism and the fun... |
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| Keywords: | HiHiLo HIF-2a/EPAS1 gene molecule genetics marker cardiac function |
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