Influence of green tea polyphenols on mitochondrial permeability transition pore and Ca2+ transport |
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| Authors: | Shen Sheng-rong Yu Hai-ning Jin Chao-fang |
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| Institution: | (1) Department of Tea Sciences, Zhejiang University, 310029 Hangzhou, China |
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| Abstract: | The authors investigated the influence of green tea polyphenols (GTPs) on the liver mitochondria permeability transition pore
(PTP) opening through mitochondria swelling and change of mitochondria membrane potential. The data showed that GTPs had obvious
protective effect on the Ca2+-induced PTP opening in a dose-dependent manner detected by mitochondria swelling. The results were obtained by measuring
the change of mitochondria membrane potential through Rh 123. Further experiments were conducted to examine the detailed influence
of GTPs on Ca2+ import and export of mitochondria. The results showed that GTPs had remarkably inhibitory effect on the Ca2+-induced Ca2+ import in mitochondria; and that they could accelerate Ca2+-release from mitochondria. Our data provide an alternate interpretation of the potent protective function of GTPs on cell
against apoptosis. |
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| Keywords: | Mitochondria PTP green tea polyphenols mCICR Ca2+ transport Mitochondria Δ Ψ m |
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