Microfluidic devices for studying heterotypic cell-cell interactions and tissue specimen cultures under controlled microenvironments |
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| Authors: | Zervantonakis Ioannis K Kothapalli Chandrasekhar R Chung Seok Sudo Ryo Kamm Roger D |
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| Institution: | 1Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02319, USA;2Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA;3School of Mechanical Engineering, Korea University, Seoul 136-713, South Korea;4Department of System Design Engineering, Keio University, Yokohama 223-8522, Japan |
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| Abstract: | Microfluidic devices allow for precise control of the cellular and noncellular microenvironment at physiologically relevant length- and time-scales. These devices have been shown to mimic the complex in vivo microenvironment better than conventional in vitro assays, and allow real-time monitoring of homotypic or heterotypic cellular interactions. Microfluidic culture platforms enable new assay designs for culturing multiple different cell populations and∕or tissue specimens under controlled user-defined conditions. Applications include fundamental studies of cell population behaviors, high-throughput drug screening, and tissue engineering. In this review, we summarize recent developments in this field along with studies of heterotypic cell-cell interactions and tissue specimen culture in microfluidic devices from our own laboratory. |
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