| 针刺预处理对全脑缺血大鼠微血管损伤及脑水肿的保护作用 |
| |
| 引用本文： | 唐伟,王威,白鹰,王卓尔.针刺预处理对全脑缺血大鼠微血管损伤及脑水肿的保护作用[J].大连大学学报,2007,28(3):65-68. |
| |
| 作者姓名： | 唐伟 王威 白鹰 王卓尔 |
| |
| 作者单位： | 1. 大连大学,附属新华医院,辽宁,大连,116021
2. 大连理工大学,神经信息研究所,辽宁,大连,116023 |
| |
| 摘 要： | 目的]针刺预处理对全脑缺血大鼠微血管损伤及脑水肿的保护作用.方法]采用四动脉阻断法制作大鼠全脑缺血模型,针刺预处理组:术前给予针刺,针刺7 d后给予全脑缺血10 min,干湿法测脑组织水含量,应用HE染色、TUNEL染色及透射电镜技术,观察大鼠脑缺血后,组织病理学及超微结构改变.结果]与脑缺血组相比,针刺预处理组不引起明显的神经元损伤,全脑缺血10 m in后72 h,微血管损伤及脑水肿明显减轻,血管内皮细胞凋亡减少.结论]针刺预处理能够通过减轻微血管损伤及脑水肿对脑缺血产生保护作用.
|
| 关 键 词： | 脑缺血 针灸疗法 脑水肿 缺血预处理 内皮细胞 |
| 文章编号： | 1008-2395（2007）03-0065-04 |
| 修稿时间： | 2007-03-25 |
Protection of Acupuncture Preconditioning Against Microvascular Injury and Brain Edema in Global Ischemic Rats |
| |
| TANG Wei,WANG Wei,BAI Ying,WANG Zhuo-er.Protection of Acupuncture Preconditioning Against Microvascular Injury and Brain Edema in Global Ischemic Rats[J].Journal of Dalian University,2007,28(3):65-68. |
| |
| Authors: | TANG Wei WANG Wei BAI Ying WANG Zhuo-er |
| |
| Institution: | 1. Xinhua Hospital Affiliated of Dalian University, Dalian 116021, China; 2. Neuroinformatics Institute of Dalian University of Technology, Dalian 116024, China |
| |
| Abstract: | Objective]To explore the protection of acupuncture preconditioning against microvascular injury and brain edema in global ischemic rats.Methods]To prepare global ischemic model by four-vessel occlusion method.Seven days before 10 min global ischemia,the rats received acupuncture in acupuncture preconditioning group.The water content were evaluated by dry-wet method.The pathohistology and ultrastructure were observed by HE staining,TUNEL staining and transmission electron microscopy.Results]To compare brain ischemic group with acupuncture preconditioning group,microvascular injury and brain edema relieved obviously and vascular endothelial cell apotosis decreased in the later.Conclusion]Acupuncture preconditioning can protect against brain ischemia by reducing microvascular injury and brain edema. |
| |
| Keywords: | cerebral ischemia acupuncture brain edema ischemic preconditioning endothelial cell |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
