Some network thermodynamic models of coupled,dynamic physiological systems |
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| Authors: | DC Mikulecky SR Thomas |
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| Institution: | Department of Physiology, Medical College of Virginia, Richmond, VA 23298, U.S.A. |
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| Abstract: | A network thermodynamic method is presented which utilizes SPICE2, a computer program for simulating nonlinear electrical circuits, to model and simulate a number of nonlinear, dynamic physiological systems. Ordinary circuit diagrams are presented along with bond graph representations to facilitate translation into the simulation language. Examples discussed are a compartmental model of sodium flow in frog skin, coupled salt and volume flow in kidney proximal tubule and a cancer chemotherapeutic agent's permeation and metabolism in a cancer cell. |
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