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Effects of atorvastatin on progression of diabetic nephropathy and local RAGE and soluble RAGE expressions in rats |
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| Authors: | Lu Lin Peng Wen-Hui Wang Wei Wang Ling-Jie Chen Qiu-Jing Shen Wei-Feng |
| Institution: | (1) Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University School of Medicine, 1-4-3, Asahi-machi, Abeno, Osaka 545-8585, Japan |
| Abstract: | ObjectiveAdvanced glycation end-products (AGEs) exert inflammatory and oxidative stress insults to produce diabetic nephropathy mainly through the receptor for AGEs (RAGE). This study aimed to assess the effect of atorvastatin on diabetic nephropathy via soluble RAGE (sRAGE) and RAGE expressions in the rat kidney. |
| Keywords: | Receptor for advanced glycation end-product (RAGE) Endogenous secretory RAGE (esRAGE) Soluble RAGE (sRAGE) Diabetic nephropathy Atorvastatin |
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