| 运动应激性胃溃疡动物模型的建立及其行为学评价 |
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| 引用本文： | 胡柏平,倪静.运动应激性胃溃疡动物模型的建立及其行为学评价[J].体育科学,2007,27(11):55-60. |
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| 作者姓名： | 胡柏平 倪静 |
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| 作者单位： | 陕西师范大学,体育学院,陕西,西安,710062 |
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| 摘 要： | 目的：探讨运动应激性胃溃疡动物模型建立的可行性和行为学评价方法。方法：雌性SD大鼠随机分组,实验测试指标有：旷场实验、暗盒实验、内脏疼痛指数行为学指标变化,动物摄食量和体重变化,以及溃疡指数,血清皮质醇含量。结果：1）力竭组大鼠溃疡指数显著升高（P〈0.01）,运动应激动物体重、摄食量显著下降;2）力竭组大鼠矿场实验中的水平运动、垂直运动得分显著下降（P〈0.01）,表明大鼠的活动能力水平和活动兴趣均下降;理毛次数显著减少（P〈0.01）,表明大鼠的清洁行为明显减少;暗环境适应能力下降（P〈0.01）,内脏疼痛行为表现显著增加（P〈0.01）。3）力竭组大鼠血清皮质醇含量显著性升高（P〈0.01）。结论：旷场、暗盒和内脏疼痛指数实验可以作为评价雌性大鼠力竭性跑台训练导致运动应激性胃溃疡模型的行为学测试方法。
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| 关 键 词： | 运动应激性胃溃疡 动物模型 行为学 矿场实验 暗盒实验 溃疡指数 内脏疼痛指数 |
| 文章编号： | 1000-677X（2007）11-0055-06 |
| 收稿时间： | 2007-08-21 |
| 修稿时间： | 2007-10-12 |
Establishment and Behavior Evaluation of Exercise Stress Gastric Ulcer Model |
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| HU Bai-ping,NI Jing.Establishment and Behavior Evaluation of Exercise Stress Gastric Ulcer Model[J].China Sport Science,2007,27(11):55-60. |
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| Authors: | HU Bai-ping NI Jing |
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| Abstract: | The purpose of this study was to analyze the validity,reliability and utility of the exercise stress gastric ulcer model. The SD female rats were randomly divided into group. Body weight,daily food intake,open-field test,black-box test and the index of evisceral pain were investigated during the whole procedur;and detecting the Ulcer index,the contents Cortisol (CORT). The result showed that ulcer index of exercise-induced exhaustion group increased sharply (P<0.01). Rats exposed to exercise stress showed decreased body weight and food intake. Squares crossed,rears and grooming in open-field test of exercise-induced exhaustion group reduced obviously(P<0.01)and showed that the level of activity and interest in activities both declined;the frequency of combing their hair reduced obviously(P<0.01),the rats cleaning behavior reduced obviously;dark-environment adapt ability weakened obviously (P<0.01);Index of evisceral pain behavior of rads goes up sharp(P<0.01). The contents cortisol of exercise-induced exhaustion group rats go up salience (P<0.01). It concludes that female rats exhausting running exercise is reliability way to reproduce the model of exercise stress gastric ulcer. |
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| Keywords: | exercise stress gastric ulcer model animal model behavior open- field test black-box test ulcer index index of evisceral pain |
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