| 髓系来源的免疫抑制性细胞免疫调节作用的研究进展 |
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| 引用本文： | 张帆,郭亚军.髓系来源的免疫抑制性细胞免疫调节作用的研究进展[J].安康学院学报,2013(3):38-41. |
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| 作者姓名： | 张帆 郭亚军 |
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| 作者单位： | 解放军总医院肿瘤中心,北京100853 |
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| 基金项目： | 国家自然科学基金“髓系抑制性细胞在类风湿性关节炎的作用及机制研究”（81172853/H1008） |
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| 摘 要： | 髓系来源的免疫抑制性细胞(Myeloid-derived suppressor cells,MDSC)是一群异质性免疫细胞,在肿瘤发生发展、感染和炎症等疾病进程中扩增,能够明显抑制T细胞的免疫反应。MDSC在机体免疫调节中发挥了独特的作用。本文综述了MDSC的来源、功能和其作为潜在肿瘤免疫治疗靶点的意义。
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| 关 键 词： | 免疫抑制 肿瘤发生 感染 炎症 |
Progress in Immune-Suppressive Effects of Myeloid Sources Mydoid Derived Suppressor Cells |
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| ZHANG Fan,GUO Yajun.Progress in Immune-Suppressive Effects of Myeloid Sources Mydoid Derived Suppressor Cells[J].Journal of Ankang Teachers College,2013(3):38-41. |
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| Authors: | ZHANG Fan GUO Yajun |
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| Institution: | (Tumor Center, PLA General Hospital,Beijing 100853,China) |
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| Abstract: | The myeloid--defived suppressor cell （MDSC） is a group of the heterogeneity immune ceils. MDSC which would be amplified in tumor development, infection and inflammation, could inhibit T cell immune response. It plays certain roles in human immune regula-tion. By participated the regulation of human major diseases, MDSC would be a potential and novel tumor immunotherapy targets. In this paper, we review the progress in the function, source and regulation of MDSC. |
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| Keywords: | immune suppression tumor progress infection reaction inflammation response |
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