Risk factors for coronary heart disease in type II diabetes mellitus |
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| Authors: | H Surekha Rani G Madhavi V Ramachandra Rao B K Sahay A Jyothy |
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| Institution: | (1) Dept. of Cell Biology, Institute of Genetics amd Hospital for Genetic Diseases, Osmania University, Begumpet, 16 Hyderabad;(2) Sahay’s Diabetic Clinic and Research Centre, “My Nest” 6-3-852/A, 500 016 Ameerpet, Hyderabad;(3) Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, 500 016 Hyderabad |
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| Abstract: | Cardiovascular complications are the major cause of morbidity and mortality in diabetic patients. An attempt has been made
to evaluate the risk factors for coronary heart disease in type II diabetics. In the present study the levels of fasting and
postprandial plasma glucose, total cholesterol, low density lipoproteins, triglycerides were high and the levels of high density
lipoproteins were low in the type II diabetics compared to controls. The markers of free radical induced injury i.e. malondialdehyde
and nitrite/nitrate were high while total antioxidant status a marker for antioxidant protection against reactive oxygen species
was low in diabetics compared to controls. The study therefore suggests the importance of assessing these markers of oxidative
stress and antioxidant capacity along with the other routine investigations in diabetic patients for initiating antioxidant
therapy in addition to primary and secondary preventive measures to mitigate the devastating consequences of diabetes leading
to coronary heart disease. |
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| Keywords: | Type II Diabetes Mellitus Coronary Heart Disease Risk factors Oxidative stress Total antioxidant status |
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