| VEGF在膀胱移行细胞癌中的表达及临床意义 |
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| 引用本文： | 陶华志,俞俊杰,顾晓.VEGF在膀胱移行细胞癌中的表达及临床意义[J].泰州职业技术学院学报,2007,7(4):47-49,52. |
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| 作者姓名： | 陶华志 俞俊杰 顾晓 |
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| 作者单位： | 江苏省苏北人民医院泌尿外科,江苏,扬州,225001 |
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| 摘 要： | 目的：探讨血管内皮生长因子（VEGF）在膀胱移行细胞癌中的表达及临床意义。方法：采用免疫组化、ELISA方法对45例膀胱移行细胞癌组织、血浆和10例正常膀胱黏膜组织、30例正常成人血浆中VEGF进行检测分析。结果：VEGF在膀胱移行细胞癌患者中呈高表达，且随分期、分级的增高而增高；膀胱癌手术前患者血浆中VEGF的浓度高于手术后。结论：1．VEGF的表达与膀胱移行细胞癌的病理分级、临床分期及生物学行为有密切关系；2．血浆中VEGF水平可有助于预测膀胱癌患者手术疗效。
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| 关 键 词： | 膀胱移行细胞癌 血管内皮生长因子 肿瘤 |
| 文章编号： | 1671-0142（2007）04-0047-03 |
Expression of VEGF in Human Transitional Cell Carcinoma of Bladder and Its Clinical Significance |
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| TAO Hua-zhi,YU Jun-jie,GU Xiao.Expression of VEGF in Human Transitional Cell Carcinoma of Bladder and Its Clinical Significance[J].Journal of Taizhou Polytechnical Institute,2007,7(4):47-49,52. |
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| Authors: | TAO Hua-zhi YU Jun-jie GU Xiao |
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| Abstract: | Objective To investigate the expression of VEGF in human transitional cell carcionoma of bladder(BTCC) and discuss its clinical significance.Methods Using immunohistochemical stains and enzyme-Linked immunosorbent assay,the expression of VEGF of 45 cases of bladder carcinoma tissue,plasma(tumor group) and 10 cases of normal bladder tissue,30 normal adult plasmas were analyzed.Results VEGF was highly expressed in tumor samples and its expression rates increased with grades and stages.The plasma VEGF concentration of BTCC group before operation was higher than that of after operation.Conclusion 1.Expression of VEGF has a close relationship with pathology graduation,clinical by stages and Biology behavior of BTCC;2.In the blood plasma the VEGF level may be helpful to the forecast carcinoma of bladder patient surgery curative effect. |
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| Keywords: | vascular endothelial growth factor(VEGF) transitional cell carcionoma of bladder cancer |
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