| 运动,活性氧与阿尔茨海默病 |
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| 引用本文： | 赵永军.运动,活性氧与阿尔茨海默病[J].体育科学研究,2010,14(4):90-94. |
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| 作者姓名： | 赵永军 |
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| 作者单位： | 华东师范大学体育与健康学院,上海200241 |
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| 摘 要： | 对近些年来关于ROS在AD发生发展中的机理进行分析,探讨运动预防及延缓AD发生的机制;活性氧（reac-tive oxygen species,ROS）在阿尔茨海默病（Alzheimer s disease,AD）中的作用机理以及运动对活性氧诱导的阿尔茨海默病的影响。结果表明：AD的发生发展与活性氧密切相关,活性氧参与AD病理性特征的老年斑和神经纤维缠结形成,并且促进神经元死亡。运动作为干预条件可以有效地预防和延缓活性氧诱导的AD症。活性氧对AD的发生起重要作用,运动可预防和延缓AD的发生。
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| 关 键 词： | 阿尔茨海默病 活性氧 氧化应激 运动干预 |
Exercise,Oxidative Stress and Alzheimer Disease |
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| ZHAO Yong-jun.Exercise,Oxidative Stress and Alzheimer Disease[J].Sports Sciences Researches,2010,14(4):90-94. |
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| Authors: | ZHAO Yong-jun |
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| Institution: | ZHAO Yong-jun(Physical Education ＆ Health College,East China Normal University,Shanghai 200241,China) |
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| Abstract: | The paper aims to investigate the role of oxidative stress in the pathogenesis of Alzheimer disease and to study the effect of exercise on preventing and treating this disease.Method： to analyze the studies about the evidence and possible mechanism about the oxidative stress involved in Alzheimer disease.Result： Oxidative stress is involved in all the three pathological features of AD,Senile plaques,neurofibrillary tangles and neuronal death while exercise can act as a therapy to prevent and postpone the invasion of AD.Conclusion：Oxidative damage plays an important role in the attack of AD,while exercise can prevent and postpone the attack of this disease. |
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| Keywords: | Alzheimer disease ROS Oxidative stress exercise |
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