| Structural Aberrations of Cellular Sialic Acids and their Functions in Cancer Metastases |
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| 作者姓名： | LuDa－yong CAOJing－yi |
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| 作者单位： | SchoolofLifeSciences,ShanghaiUniversity,Shanghai200436 |
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| 基金项目： | theScienceFoundationofShanghaiMunicipalof
Education!(97A49) |
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| 摘 要： | Sialic acids (neuraminic cids)are a special series of 9-carbon ring negatively charged carbohydrates,which has been found to be selectively changed in malignant cells from structures(both synthesis and structure modifications)to functions(up and down regulation in cells),Sialic acids,in single forms or conjugates.have been systematically studied both in lab and in clinics by GC,GCMS,NMR,HPTLC,HPLC and other modern analytical means.Sialic acids and related conjugates are predicted to be used in cancer diagnosis,cancer prognostic forecasting,designing of cancer chemotherapy regimens,uncovering carcinogenetic processes and neoplasm metastasis.Tumor cell regulative system and pathways are correlated with sialic acids,which can be applied to prognostic evaluation of cancer patients,and antimetastatic chemotherapy by sialic acid derivatives and analogues,Searching for new biological characteristics of sialic acids in cells have also been extensively studied these days.In this paper,main stream discoveries and advancements are provided.also discussions of possible mechanisms and hypotheses are invoked.
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| 关 键 词： | 癌 诊断 细胞唾液酸 结构失常 |
| 收稿时间： | 27 December 2000 |
Structural aberrations of cellular sialic acids and their functions in cancer metastases |
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| Da-yong Lu,Jing-yi Cao.Structural Aberrations of Cellular Sialic Acids and their Functions in Cancer Metastases[J].Journal of Shanghai University(English Edition),2001,5(2):164-170. |
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| Authors: | Da-yong Lu Jing-yi Cao |
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| Institution: | School of Life Sciences, Shanghai University, |
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| Abstract: | Sialic acids (neuraminic acids) are a special series of 9 carbon ring negatively charged carbohydrates, which has been found to be selectively changed in malignant cells from structures (both synthesis and structure modifications) to functions (up and down regulation in cells). Sialic acids, in single forms or conjugates, have been systematically studied both in lab and in clinics by GC, GC MS, NMR, HPTLC, HPLC and other modern analytical means. Sialic acids and related conjugates are predicted to be used in cancer diagnosis, cancer prognostic forecasting, designing of cancer chemotherapy regimens, uncovering carcinogenetic processes and neoplasm metastasis. Tumor cell regulative systems and pathways are correlated with sialic acids, which can be applied to prognostic evaluation of cancer patients, and antimetastatic chemotherapy by sialic acid derivatives and analogues. Searching for new biological characteristics of sialic acids in cells have also been extensively studied these days. In this paper, main stream discoveries and advancements are provided , also discussions of possible mechanisms and hypotheses are invoked. |
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| Keywords: | sialic acid neoplasm metastasis cancer diagnosis cancer pathology cancer chemotherapy |
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