| 冠心病患者树突状细胞功能状态分析 |
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| 引用本文： | 陈铁明,吕永恒,陈琪,沈宏友,黎洪展.冠心病患者树突状细胞功能状态分析[J].雁北师范学院学报,2007,23(2):70-72. |
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| 作者姓名： | 陈铁明 吕永恒 陈琪 沈宏友 黎洪展 |
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| 作者单位： | 南方医科大学中医药学院,广东广州,510315 |
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| 摘 要： | 通过分离CHD患者及健康体检者外周血单个核细胞(PBMC),在含粒细胞巨噬细胞集落刺激因子(GM-CSF)、白介素4(IL-4)的培养条件下制备树突状细胞(DC),并应用流式细胞仪检测DC表面共刺激分子CD86(B7-2)的表达、混合淋巴细胞反应(MLR),检测DC对同种异体淋巴细胞的刺激能力,分析评价冠心病(CHD)患者DC的功能状态,结果表明,CHD患者DC处于激活状态,此可能是CHD发病机制之一.
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| 关 键 词： | 冠心病 动脉粥样硬化 树突状细胞 C反应蛋白 |
| 文章编号： | 1009-1939（2007）02-0070-03 |
| 修稿时间： | 2006-12-15 |
Function of Dendritic Cells in Patients with Coronary Heart Disease |
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| CHEN Tie-ming,LV Yong-heng,CHEN Qi,SHEN Hong-you,LI Hong-dian.Function of Dendritic Cells in Patients with Coronary Heart Disease[J].Journal of Yanbei Teachers College,2007,23(2):70-72. |
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| Authors: | CHEN Tie-ming LV Yong-heng CHEN Qi SHEN Hong-you LI Hong-dian |
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| Institution: | School of Chinese Medicine, Southern Medical University, Guangzhou Guangdong 510315 |
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| Abstract: | DCs were derivedfromhuman monocytes upon culture withinterleukin(IL)-4 andgranulocyte macrophage colony sti mulating factor(GM-CSF) from20 patients with CHD and 20 healthy subjects.Surface costi mulatory factor CD86(B7-2) of DCs were assessed by flowcytometry.I mmunosti mulatory capacity was measured by mixedlymphocyte reaction(MLR).The results indicated that DCs of patients with CHDare activated,which may play ani mportant role in the progress of CHD. |
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| Keywords: | Key Wards :coronary heart disease atherosclerosis dendritic cells C reactive protein |
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