| 小鼠实验性缺氧脑和肺组织MDA、LD及LDH的变化(英文) |
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| 引用本文： | 李海峰,李英,范红斌,李鑫.小鼠实验性缺氧脑和肺组织MDA、LD及LDH的变化(英文)[J].河北北方学院学报(医学版),2010,27(1):23-26. |
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| 作者姓名： | 李海峰 李英 范红斌 李鑫 |
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| 作者单位： | 1. 河北北方学院实验中心电镜室,河北,张家口,075000
2. 江南大学医药学院,江苏,无锡,214122 |
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| 摘 要： | 目的：探讨小鼠实验性缺氧脑和肺组织丙二醛（Malondialdehyde，MDA）、乳酸（Lactic acid，LD）含量和乳酸脱氢酶（Lactate dehydrogenase，LDH）活性变化。方法：18只小鼠随机分为3组，①正常对照组；②急性缺氧组；③急性一氧化碳染毒组。分别测定脑和肺组织MDA、LD、LDH含量和活性。结果：急性缺氧组和急性一氧化碳染毒组小鼠脑和肺组织MDA和LD含量显著增高。LDH活性在两实验组小鼠肺组织显著降低，而在脑组织无显著性改变。结论：MDA和LD含量在缺氧早期脑和肺组织是易变化性指标，其改变可能与该组织损伤程度有关。肺较脑对缺氧产生的自由基损伤更敏感。
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| 关 键 词： | 缺氧 丙二醛 乳酸 乳酸脱氢酶 |
Changes of MDA,LD and LDH in Brain and Lung with Experimental Anoxia in Mice |
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| LI Hai-feng,LI Ying,FAN Hong-bin,LI Xin.Changes of MDA,LD and LDH in Brain and Lung with Experimental Anoxia in Mice[J].Journal of Hebei North University:Medical Edition,2010,27(1):23-26. |
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| Authors: | LI Hai-feng LI Ying FAN Hong-bin LI Xin |
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| Institution: | LI Hai-feng1,LI Ying2,FAN Hong-bin2,LI Xin11.Dep.of Electron Microscope,Hebei North University,Zhangjiakou,075000,Hebei,China2.School of Medicine , Pharmaceutics,Jiangnan University,Wuxi,214122,Jiangsu,China |
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| Abstract: | Objective:To determine the levels of malondialdehyde(MDA),Lactic acid,(LD)and activity of Lactate dehydrogenase(LDH)for mice with experimental anoxia.Methods:18 mice were randomly divided into three groups.Mice in group 1 served as no hypoxic control,mice in Group 2 were subjected to acute hypo-baric hypoxic exposure and mice in group 3 were subjected to CO poisoning.All animals were killed after 40 min.Brain and lung specimens were obtained to determine the tissue level of MDA,LD and activity of LDH.Result... |
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| Keywords: | Anoxia Melondialdehyde Lactic acid Lactate dehydrogenase |
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