| 苯并香豆素缀N3O2大环化合物的合成及与CT DNA的相互作用研究 |
| |
| 引用本文： | 陈稼轩,熊俊如,张丽群,刘素君,田 怡.苯并香豆素缀N3O2大环化合物的合成及与CT DNA的相互作用研究[J].乐山师范学院学报,2013(12):30-32. |
| |
| 作者姓名： | 陈稼轩 熊俊如 张丽群 刘素君 田 怡 |
| |
| 作者单位： | 乐山师范学院化学学院,乐山614000 |
| |
| 基金项目： | 四川省科技厅应用基础项目（201UYZ006、2009JY0078）;乐山市科技局重点项目（2011SZD107） |
| |
| 摘 要： | 以1，12，15-三氮杂-3，4：9，10-二苯并-5，8-二氧杂环十七烷为原料，合成了含苯并香豆素缀N3O2大环化合物，其结构经1H NMR，MS，元素分析等表征。通过紫外光谱法和荧光光谱法研究表明：目标化合物通过嵌插方式与DNA相互结合。
|
| 关 键 词： | 苯并香豆素 N3O2大环 相互作用 |
Studies on the Synthesis of the N3O2-Donor Macrocycle Bearing Benzocoumarin Group and its Interaction with CT DNA |
| |
| CHEN Jiaxuan,XIONG Junru,ZHANG Liqun,LIU Sujun,TIAN Yi.Studies on the Synthesis of the N3O2-Donor Macrocycle Bearing Benzocoumarin Group and its Interaction with CT DNA[J].Journal of Leshan Teachers College,2013(12):30-32. |
| |
| Authors: | CHEN Jiaxuan XIONG Junru ZHANG Liqun LIU Sujun TIAN Yi |
| |
| Institution: | (School of Chemistry, Leshan Normal Univerity, Leshan Sichuan 614000, China) |
| |
| Abstract: | A N3O2-donor macrocyclic comp ound bearing benzocoumarin group is obtained from 1, 12, 15-triaza-3, 4：9, 10-dibenzo-5, 8-dioxacycloheptadecane, the structure of which is characterized by 1H NMR, MS spectra and elemental analysis. Interactions of the target compound with CT （calf thymus） DNA have been investigated by the ultraviolet spectrophotometry and fluorescence spectrophotometry. The results shows that the binding model is intercalated. |
| |
| Keywords: | 小牛胸腺DNA Benzocoumarin N3O2-donor Macrocycle CT DNA Interaction |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
