LP(a) phenotypes and levels in angiographically proven coronary heart disease patients and controls |
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| Authors: | Kalpana Luthra Suman Vasisht Shivani Chhabra K R Raju D P Agarwal S C Manchanda L M Srivastava |
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| Institution: | (1) Department of Biochemistry, CN Centre, All India Institute of Medical Sciences, 110029 New Delhi;(2) Department of Cardiology, CN, All India Institute of Medical Sciences, 110029 New Delhi;(3) Institute of Human Genetics University of Hamburg, Butenfield, 22529 Hamburg, Germany |
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| Abstract: | Lipoprotein Lp(a) excess has been identified as a powerful predictor of premature atherosclerotic vascular diseases. To evaluate
this in a North-Indian population, 130 CAD patients and 130 controls were analyzed. The size of the apo(a) phenotypic isoforms
was inversely proportional to Lp(a) concentrations. The mean concentration of Lp(a) in the CAD patients was 42±34 mg/dl whereas
in the normal subjects it was much lower, 27±27 mg/dl. 157 subjects out of the total 260 subjects showed plasma levels of
>20mg/dl. The frequency of high Lp(a) levels was much higher in patients(73%) than controls (43%). These data suggest (1)
that there is heterogeneity of the Lp(a) polymorphism, (2) Higher Lp(a) levels were found in patients than in the controls,
(3) Patients showed 1.5 fold increase in Lp(a) levels as compared to the controls. We conclude that low molecular weight apo(a)
isoforms are significantly associated with increased risk of CAD in the North-Indian population. |
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| Keywords: | Lipoprotein(a) Apolipoprotein(a) Cholesterol Coronary artery disease |
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